Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 67: 1024-1031, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 67, Issue 3 1024-1031, Copyright © 1989 by American Physiological Society

ARTICLES

Respiratory elastic load compensation in anesthetized patients with kyphoscoliosis

A. Baydur, S. M. Swank, C. M. Stiles and C. S. Sassoon
Chest Medicine Service, Rancho Los Amigos Medical Center, Downey, California 90242.

To evaluate the effects of abnormal respiratory mechanics and neuromuscular drive on the various components of elastic load compensation, we studied 16 anesthetized patients with kyphoscoliosis whose mean passive and active respiratory elastance (Ers and E'rs, respectively), active respiratory resistance, and peak inspiratory occlusion pressure were, respectively, 89, 84, 100, and 37% greater and inspiratory duration (TI) 13% less than corresponding values in 13 anesthetized controls. Ers comprised approximately 66% of effective elastance (E*rs) in both groups. E'rs, reflecting the role of the force-length properties of the active inspiratory muscles in increasing the internal impedance, comprised 83.8 and 86.1% of E*rs in the kyphoscoliosis patients and controls, respectively (P less than 0.001). This demonstrates the influence of increased intrinsic elastance and resistance and decreased TI on tidal volume defense in kyphoscoliosis patients in the absence of vagal modulation. In some patients the difference between Ers and E*rs was substantial, despite an unchanged or even shortened TI, suggesting that the Hering-Breuer reflex may affect stability through ways other than altering TI (e.g., via graded volume-dependent "terminal inhibition"). Characteristics of elastic load compensation in anesthetized kyphoscoliosis patients are similar to those of anesthetized normal subjects.


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