Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 1007-1012, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davis, J. M.
Right arrow Articles by Shapiro, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davis, J. M.
Right arrow Articles by Shapiro, D. L.

Journal of Applied Physiology, Vol 67, Issue 3 1007-1012, Copyright © 1989 by American Physiological Society

ARTICLES

Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation

J. M. Davis, D. P. Penney, R. H. Notter, L. Metlay, B. Dickerson and D. L. Shapiro
Department of Pediatrics (Neonatology), University of Rochester School of Medicine and Dentistry, New York 14642.

Neonatal lung injury from hyperoxia and mechanical hyperventilation was studied in newborn piglets hyperventilated (arterial PCO2 15-20 Torr) for 24-48 h with 100% O2 and compared with unventilated controls. Pulmonary function testing was performed, and biochemical indicators of lung injury were analyzed from tracheobronchial aspirates at 0, 24, and 48 h. Lung sections were obtained for light and electron microscopy, and bronchoalveolar lavage fluid was analyzed for surfactant composition and activity. At 24 h significant changes in tracheobronchial aspirate albumin concentrations (up 78%) and percent of polymorphonuclear cells (up 16%) were demonstrated. At 48 h a 35% decrease in dynamic lung compliance (P less than 0.05) and a 36% increase in pulmonary resistance (P less than 0.05) were noted. Further biochemical abnormalities occurred with total cell counts increased by 271% (P less than 0.02), albumin 163% (P less than 0.05), total protein 217% (P less than 0.01), and elastase 108% (P less than 0.02). Pathological analyses revealed mild lung injury at 24 h and marked inflammation, abnormal inflation patterns, flattening of Clara cells, fibrinous exudate and edema, early collagen formation, and cell necrosis observed at 48 h. Bronchoalveolar lavage surfactant had normal biophysical activity. Results demonstrate that exposure of neonatal piglets to O2 and mechanical hyperventilation for 48 h cause severe progressive lung injury.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. C. Bailey, E. L. Martin, L. Zhao, and R. A. W. Veldhuizen
High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation
J Appl Physiol, March 1, 2003; 94(3): 975 - 982.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Petak, W. Habre, Y. R. Donati, Z. Hantos, and C. Barazzone-Argiroffo
Hyperoxia-induced changes in mouse lung mechanics: forced oscillations vs. barometric plethysmography
J Appl Physiol, June 1, 2001; 90(6): 2221 - 2230.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online