Journal of Applied Physiology, Vol 67, Issue 3 1001-1006, Copyright © 1989 by American Physiological Society

ARTICLES

Bronchial artery ligation modifies pulmonary edema after exposure to smoke with acrolein

C. A. Hales, P. Barkin, W. Jung, D. Quinn, D. Lamborghini and J. Burke
Department of Medicine (Pulmonary Unit), Massachusetts General Hospital, Harvard Medical School, Boston 02114.

Pulmonary edema can follow smoke inhalation and is believed to be due to the multiple chemical toxins in smoke, not the heat. We have developed a synthetic smoke composed of aerosolized charcoal particles to which one toxin at a time can be added to determine whether it produces pulmonary edema. Acrolein, a common component of smoke, when added to the synthetic smoke, produced a delayed-onset pulmonary edema in dogs in which the extravascular lung water (EVLW) as detected by a double-indicator technique began to rise after 42 +/- 2 (SE) min from 148 +/- 16 to 376 +/- 60 ml at 165 min after smoke exposure. The resulting pulmonary edema was widespread macroscopically but appeared focal microscopically with fibrin deposits in alveoli adjacent to small bronchi and bronchioles. Bronchial vessels were markedly dilated and congested. Monastral blue B when injected intravenously leaked into the walls of the bronchial vessels down to the region of the small bronchioles (less than or equal to 0.5 mm ID) of acrolein-smoke-exposed dogs but not into the pulmonary vessels. Furthermore, ligation of the bronchial arteries delayed the onset of pulmonary edema (87 +/- 3 min, P less than 0.05) and lessened the magnitude (232 +/- 30 ml, P less than 0.05) at 166 +/- 3 min after acrolein-smoke exposure.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				P. Enkhbaatar, K. Murakami, K. Shimoda, A. Mizutani, R. McGuire, F. Schmalstieg, R. Cox, H. Hawkins, J. Jodoin, S. Lee, et al. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R366 - R372. [Abstract] [Full Text] [PDF]

				O. Efimova, A. B. Volokhov, S. Iliaifar, and C. A. Hales Ligation of the bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke J Appl Physiol, March 1, 2000; 88(3): 888 - 893. [Abstract] [Full Text] [PDF]

				E. M. Wagner, S. Blosser, and W. Mitzner Bronchial vascular contribution to lung lymph flow J Appl Physiol, December 1, 1998; 85(6): 2190 - 2195. [Abstract] [Full Text] [PDF]

				H. Sakurai, R. Johnigan, Y. Kikuchi, M. Harada, L. D. Traber, and D. L. Traber Effect of reduced bronchial circulation on lung fluid flux after smoke inhalation in sheep J Appl Physiol, March 1, 1998; 84(3): 980 - 986. [Abstract] [Full Text] [PDF]

				Q. J. Li and L. J. Janssen Membrane currents in canine bronchial artery and their regulation by excitatory agonists Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1358 - L1365. [Abstract] [Full Text] [PDF]