Journal of Applied Physiology
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J Appl Physiol 67: 445-452, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 67, Issue 1 445-452, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of pH on pulmonary vascular tone, reactivity, and arachidonate metabolism

I. S. Farrukh, G. H. Gurtner, P. B. Terry, W. Tohidi, J. N. Yang, N. F. Adkinson Jr and J. R. Michael
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.

We studied the effects of perfusate pH on pulmonary vascular tone, reactivity, and thromboxane and prostacyclin synthesis in isolated buffer-perfused rabbit lungs. Extracellular acidosis did not affect base-line vascular tone, but alkalosis had a biphasic effect. Increasing the perfusate pH from 7.40 to 7.65 caused vasodilation, whereas raising pH to 7.70-8.10 caused vasoconstriction. Removing calcium (Ca2+) from the perfusate completely prevented the vasoconstriction caused by alkalosis. Perfusate pH strikingly affected pulmonary vascular reactivity. Acidosis inhibited the vasoconstriction caused by thromboxane and potassium chloride (KCl) but did not affect the response to angiotensin II. Alkalosis, in contrast, augmented the vasoconstriction caused by thromboxane and angiotensin II but reduced the vasoconstriction caused by KCl. Changes in pH also altered thromboxane and prostacyclin synthesis after the infusion of exogenous arachidonic acid (AA) or the endogenous release of AA by the lipid peroxide tert-butyl hydroperoxide.


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