| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 1 256-263, Copyright © 1989 by American Physiological Society
ARTICLES |
D. M. Rotto, C. L. Stebbins and M. P. Kaufman
Department of Internal Medicine, University of California, Davis 95616.
Static exercise increases arterial pressure, heart rate, and ventilation, effects which are believed in part to arise reflexly from a metabolic stimulus in the working muscle. In anesthetized cats, we tested the hypothesis that intra-arterial injections of lactic and hydrochloric acid, which created levels of these substances in muscle similar to those seen during contraction, reflexly increased cardiovascular and ventilatory function. Hydrochloric acid (32 and 57 mM; 1 ml) injected into the arterial supply of the triceps surae decreased intramuscular pH from 7.26 +/- 0.05 to 7.17 +/- 0.05 (P less than 0.01) and reflexly increased arterial pressure (23 +/- 7 mmHg; P less than 0.01), heart rate (11 +/- 2 beats/min; P less than 0.001), and ventilation (187 +/- 72 ml/min; P less than 0.05). Static contraction of the triceps surae decreased intramuscular pH from 7.28 +/- 0.06 to 7.13 +/- 0.06 (P less than 0.01). Lactic acid was more potent in causing reflexes than was equimolar HCl. For example, lactic acid containing 4 mM lactate and 0.87 mM H+ reflexly increased arterial pressure, heart rate, and ventilation, whereas 0.87 mM HCl did not. Intra-arterial sodium lactate (13 and 33 mM) at a neutral pH had no effect on these variables. We conclude that contraction-induced accumulation of H+, especially that arising from lactic acid, might provide a metabolic stimulus to evoke reflex autonomic effects.
This article has been cited by other articles:
|
|
 |
|
  S. G. Hayes, J. L. McCord, and M. P. Kaufman Role played by P2X and P2Y receptors in evoking the muscle chemoreflex J Appl Physiol, February 1, 2008; 104(2): 538 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Hayes, A. E. Kindig, and M. P. Kaufman Blockade of acid sensing ion channels attenuates the exercise pressor reflex in cats J. Physiol., June 15, 2007; 581(3): 1271 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Kindig, S. G. Hayes, R. L. Hanna, and M. P. Kaufman P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1214 - H1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Sinoway and J. Li A perspective on the muscle reflex: implications for congestive heart failure J Appl Physiol, July 1, 2005; 99(1): 5 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kindig, T. B. Heller, and M. P. Kaufman VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1867 - H1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, M. D. Maile, A. N. Sinoway, and L. I. Sinoway Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel J Appl Physiol, November 1, 2004; 97(5): 1709 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hanna and M. P. Kaufman Activation of thin-fiber muscle afferents by a P2X agonist in cats J Appl Physiol, March 1, 2004; 96(3): 1166 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Rodman, K. S. Henderson, C. A. Smith, and J. A. Dempsey Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise J Appl Physiol, September 1, 2003; 95(3): 1159 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hanna, S. G. Hayes, and M. P. Kaufman alpha ,beta -Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats J Appl Physiol, September 1, 2002; 93(3): 834 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Scott, R. Wensel, C. H. Davos, M. Kemp, A. Kaczmarek, J. Hooper, A. J.S. Coats, and M. F. Piepoli Chemical Mediators of the Muscle Ergoreflex in Chronic Heart Failure: A Putative Role for Prostaglandins in Reflex Ventilatory Control Circulation, July 9, 2002; 106(2): 214 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. LONGHURST, S. C. TJEN-A-LOOI, and L.-W. FU Cardiac Sympathetic Afferent Activation Provoked by Myocardial Ischemia and Reperfusion: Mechanisms and Reflexes Ann. N.Y. Acad. Sci., June 1, 2001; 940(1): 74 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Hayes and M. P. Kaufman Gadolinium attenuates exercise pressor reflex in cats Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2153 - H2161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Leshnower, J. T. Potts, M. G. Garry, and J. H. Mitchell Reflex cardiovascular responses evoked by selective activation of skeletal muscle ergoreceptors J Appl Physiol, January 1, 2001; 90(1): 308 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. MacLean, V. A. Imadojemu, and L. I. Sinoway Interstitial pH, K+, lactate, and phosphate determined with MSNA during exercise in humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R563 - R571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. MacLean, K. F. LaNoue, K. S. Gray, and L. I. Sinoway Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat J Appl Physiol, October 1, 1998; 85(4): 1583 - 1592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Thomas, B. Chavoshan, M. Sander, and R. G. Victor Invited Editorial on "Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise" J Appl Physiol, June 1, 1998; 84(6): 1825 - 1826. [Full Text] [PDF]
|
|
|
|
|
|
T. Hardarson, J. O. Skarphedinsson, and T. Sveinsson Importance of the lactate anion in control of breathing J Appl Physiol, February 1, 1998; 84(2): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Oelberg, A. B. Evans, M. I. Hrovat, P. P. Pappagianopoulos, S. Patz, and D. M. Systrom Skeletal muscle chemoreflex and pHi in exercise ventilatory control J Appl Physiol, February 1, 1998; 84(2): 676 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Evans, L. W. Tsai, D. A. Oelberg, H. Kazemi, and D. M. Systrom Skeletal muscle ECF pH error signal for exercise ventilatory control J Appl Physiol, January 1, 1998; 84(1): 90 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Victor, N. H. Secher, T. Lyson, and J. H. Mitchell Central Command Increases Muscle Sympathetic Nerve Activity During Intense Intermittent Isometric Exercise in Humans Circ. Res., January 1, 1995; 76(1): 127 - 131. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
