| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 1 1-13, Copyright © 1989 by American Physiological Society
ARTICLES |
I. R. Moss and J. G. Inman
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
During ontogeny, the central nervous system undergoes neuronal growth, regression, and remodeling. The development of neurotransmitter and modulator systems is a plastic process with individual temporal characteristics for each system. These characteristics include the synthesis, degradation, or uptake of neurochemicals and, largely independently, the appearance of their receptors. Message transmission during ontogeny is compounded by the variable development of these systems and by the coexistence and cofunction among these chemicals. Nine neurochemical systems are discussed: adenosine, gamma-aminobutyric acid, opioids, prostaglandins, serotonin, progesterone, substance P, thyrotropin-releasing hormone, and the catecholamines. The possible role of each of these in natural perinatal respiratory control is evaluated according to predetermined criteria. These include the presence of a substance system in respiratory-related regions, physiologically appropriate changes in its concentration in these regions, elicitation of respiratory effects by agonists and antagonists, and abolition with an antagonist of the effect of a substance during its presumed activation by a physiological process. It is suggested that excessive levels of suppressant neuromodulators or an imbalance among neurochemicals can partly explain the special features of respiratory control in the perinatal period.
This article has been cited by other articles:
|
|
 |
|
  J. J. Greer, G. D. Funk, and K. Ballanyi Preparing for the first breath: prenatal maturation of respiratory neural control J. Physiol., February 1, 2006; 570(3): 437 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pagliardini, J. Ren, R. Wevrick, and J. J. Greer Developmental Abnormalities of Neuronal Structure and Function in Prenatal Mice Lacking the Prader-Willi Syndrome Gene Necdin Am. J. Pathol., July 1, 2005; 167(1): 175 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu and M. T. T. Wong-Riley Postnatal developmental expressions of neurotransmitters and receptors in various brain stem nuclei of rats J Appl Physiol, April 1, 2005; 98(4): 1442 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu and M. T. T. Wong-Riley Developmental changes in the expression of GABAA receptor subunits {alpha}1, {alpha}2, and {alpha}3 in the rat pre-Botzinger complex J Appl Physiol, May 1, 2004; 96(5): 1825 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu and M. T. T. Wong-Riley Postnatal changes in cytochrome oxidase expressions in brain stem nuclei of rats: implications for sensitive periods J Appl Physiol, December 1, 2003; 95(6): 2285 - 2291. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Ren, S. Lee, S. Pagliardini, M. Gerard, C. L. Stewart, J. J. Greer, and R. Wevrick Absence of Ndn, Encoding the Prader-Willi Syndrome-Deleted Gene necdin, Results in Congenital Deficiency of Central Respiratory Drive in Neonatal Mice J. Neurosci., March 1, 2003; 23(5): 1569 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu and M. T. T. Wong-Riley Postnatal expression of neurotransmitters, receptors, and cytochrome oxidase in the rat pre-Botzinger complex J Appl Physiol, March 1, 2002; 92(3): 923 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Waters and K. D. Tinworth Depression of ventilatory responses after daily, cyclic hypercapnic hypoxia in piglets J Appl Physiol, March 1, 2001; 90(3): 1065 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Y. Liu and M. T. T. Wong-Riley Developmental study of cytochrome oxidase activity in the brain stem respiratory nuclei of postnatal rats J Appl Physiol, February 1, 2001; 90(2): 685 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Watson, S. E. White, J. H. Homan, L. Fraher, J. F. Brien, and A. D. Bocking The adenosine A1-receptor antagonist 8-CPT reverses ethanol-induced inhibition of fetal breathing movements J Appl Physiol, October 1, 1999; 87(4): 1333 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Watson, S. E. White, J. H. Homan, K. A. Kimura, J. F. Brien, L. Fraher, J. R. G. Challis, and A. D. Bocking Increased cerebral extracellular adenosine and decreased PGE2 during ethanol-induced inhibition of FBM J Appl Physiol, April 1, 1999; 86(4): 1410 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hilaire and B. Duron Maturation of the Mammalian Respiratory System Physiol Rev, April 1, 1999; 79(2): 325 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McCormick, C. Suguihara, J. Huang, C. Devia, D. Hehre, J. H. Bruce, and E. Bancalari Depressed ventilatory response to hypoxia in hypothermic newborn piglets: role of glutamate J Appl Physiol, March 1, 1998; 84(3): 830 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Waters, A. Laferriere, J. Paquette, C. Goodyer, and I. R. Moss Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels J Appl Physiol, August 1, 1997; 83(2): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
