Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 66: 2659-2666, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Conhaim, R. L.
Right arrow Articles by Eaton, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Conhaim, R. L.
Right arrow Articles by Eaton, A.

Journal of Applied Physiology, Vol 66, Issue 6 2659-2666, Copyright © 1989 by American Physiological Society

ARTICLES

Sequence of interstitial liquid accumulation in liquid-inflated sheep lung lobes

R. L. Conhaim, S. J. Lai-Fook and A. Eaton
Department of Preventive Medicine, University of Wisconsin, Madison 53705.

In the initial stages of pulmonary edema, liquid accumulates in the lung interstitium and appears as cuffs around pulmonary vessels. To determine the pattern, rate, and magnitude of cuff formation, we inflated sheep lungs to capacity with liquid (inflation pressure 19 cmH2O) for 3-300 min. After freezing the lobes in liquid N2, we measured perivascular cuff size and total perivascular volume in frozen blocks of each lobe and compared the results with previous measurements in dog lungs. Total cuff volume in sheep lungs reached a maximum value of 5% of air space volume, compared with 9% in dog lungs. In sheep lungs 94% of vessels greater than or equal to 0.5 mm diam and 16% of smaller vessels were surrounded by cuffs. In dog lungs these values were 99 and 47%, respectively. The ratio of cuff area to vessel area reached a maximum of 2.3 in sheep lungs and 3.4 in dog lungs. In an electrical analogue model designed to simulate cuff growth, estimated interstitial resistance to liquid flow was 6-15 times higher than similar estimates in dog lungs. These species differences might be the result of differences in the composition of the interstitial gel or to differences in the mechanical linkage between the lung parenchyma and vessel wall.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. M. Moe, R. L. Conhaim, and S. J. Lai-Fook
Interstitial albumin concentration measured during growth of perivascular cuffs in liquid-filled rabbit lung
J Appl Physiol, January 1, 2004; 96(1): 283 - 292.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. L. Qiu, L. V. Brown, S. Parameswaran, G. S. Ibbott, and S. J. Lai-Fook
Effect of concentration on albumin diffusion in lung interstitium
J Appl Physiol, August 1, 1998; 85(2): 575 - 583.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online