Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 66: 2585-2588, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gascho, J. A.
Right arrow Articles by Zelis, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gascho, J. A.
Right arrow Articles by Zelis, R.

Journal of Applied Physiology, Vol 66, Issue 6 2585-2588, Copyright © 1989 by American Physiological Society

ARTICLES

Effects of posture on the venodilatory response to nitroglycerin

J. A. Gascho, C. Fanelli, A. Sumner and R. Zelis
Division of Cardiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

To determine the effects of posture on the venodilatory response to nitroglycerin (TNG), the change in forearm venous volume after inflation of an upper arm cuff to 30 mmHg above cuff zero (VV[30]) was measured during control conditions and after TNG (0.8 mg spray) in 18 healthy young volunteers in the supine position and the sitting position. VV[30] was 3.24 +/- 0.98 ml/100 ml arm in the supine position and 2.46 +/- 1.32 ml/100 ml arm in the sitting position. TNG increased VV[30] by 0.56 +/- 0.19 ml/100 ml arm in supine subjects, but by only 0.38 +/- 0.17 ml/100 ml arm in sitting subjects (P = 0.013). When limb volume was measured in the forearm and calf without using a cuff to produce venous congestion, the increase in limb volume with TNG was significantly greater in the sitting than in the supine position. Because the fall in both systolic and diastolic pressure and the rise in heart rate were significantly greater after TNG was administered in the sitting position, it is suggested that a greater reflex venoconstriction occurred in this posture, which antagonized the TNG-induced increase in venous distensibility. In the seated position, the effect of gravity more than compensated for the impaired venodilatory response to TNG. These results suggest that TNG causes a greater reduction in venous return to the heart when administered in the sitting position than in the supine position.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. N. Young, R. Y. Prasad, A. M. Fullenkamp, M. E. Stillbower, W. B. Farquhar, and D. G. Edwards
Ultrasound assessment of popliteal vein compliance during a short deflation protocol
J Appl Physiol, May 1, 2008; 104(5): 1374 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. N. Young, M. E. Stillabower, A. DiSabatino, and W. B. Farquhar
Venous smooth muscle tone and responsiveness in older adults
J Appl Physiol, November 1, 2006; 101(5): 1362 - 1367.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online