Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 66: 2344-2350, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Montalescot, G.
Right arrow Articles by Zapol, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montalescot, G.
Right arrow Articles by Zapol, W. M.

Journal of Applied Physiology, Vol 66, Issue 5 2344-2350, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of platelet depletion on lung vasoconstriction in heparin-protamine reactions

G. Montalescot, E. Kreil, K. Lynch, E. M. Greene, A. Torres, A. Carvalho, C. Fitzgibbon, D. R. Robinson, E. Lowenstein and W. M. Zapol
Department of Anesthesia, Massachusetts General Hospital, Boston 02114.

In six awake sheep the control heparin-protamine reaction was associated with a 150-fold rise in arterial plasma thromboxane B2 (TxB2) levels, a 4.5-fold increase in pulmonary vascular resistance, a 20% decrease in cardiac output, a 30% decrease in arterial PO2, and a 30% reduction in arterial white blood cell concentrations. Depletion of 99% of circulating platelets by antibodies did not prevent either acute and severe pulmonary hypertension or increased plasma TxB2 levels induced by heparin-protamine administration. We produced sheep platelet aggregation in vitro with bovine thrombin and measured marked TxB2 release (36.3 +/- 16.3 ng/10(9) platelets). In contrast, neither heparin, protamine, nor heparin-protamine complexes over a 10,000-fold range of concentrations induced platelet aggregation and release of thromboxane in vitro. Therefore sheep platelets are not the source of thromboxane production associated with acute pulmonary hypertension during the heparin-protamine reaction, and other cells must produce the thromboxane.


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. D. Williams, M. N. D'Ambra, T. E. Maione, K. E. Lynch, and D. F. Keene
Recombinant platelet factor 4 reversal of heparin in human cardiopulmonary bypass blood
J. Thorac. Cardiovasc. Surg., November 1, 1994; 108(5): 975 - 983.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online