Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 66: 1494-1500, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frey, M. J.
Right arrow Articles by Molinoff, P. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frey, M. J.
Right arrow Articles by Molinoff, P. B.

Journal of Applied Physiology, Vol 66, Issue 3 1494-1500, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of exercise duration on density and coupling of beta-adrenergic receptors on human mononuclear cells

M. J. Frey, D. Mancini, D. Fischberg, J. R. Wilson and P. B. Molinoff
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104.

The effect of maximal exercise on lymphocyte beta-adrenergic receptors was examined in 26 normal subjects. Exercise increased O2 consumption (Vo2) from 5 +/- 1 to 50 +/- 4 ml.min-1.kg-1, plasma norepinephrine level from 188 +/- 28 to 2,682 +/- 160 pg/ml, and plasma epinephrine level from 94 +/- 72 to 857 +/- 180 pg/ml. The density of beta-adrenergic receptors on lymphocytes obtained at rest was 31 +/- 3.7 fmol/mg protein; exercise increased the density of receptors by 86 +/- 33% (range 0-257%) to 58.3 +/- 1.5 fmol/mg protein but did not alter the affinity of the receptor for [125I]iodopindolol or the coupling of the receptor to the guanine nucleotide-binding regulatory protein. The density of beta-adrenergic receptors increased progressively throughout exercise and paralleled the increase in heart rate. The magnitude of the change in the density of beta-adrenergic receptors did not correlate with the magnitude of the increase in heart rate, Vo2, or plasma levels of catecholamines. The density of receptors was still elevated 15 min after completion of exercise but fell below base line 1 h after peak exercise to 18.2 +/- 6.7 fmol/mg protein (P less than 0.05 vs. base-line levels). These results demonstrate that exhaustive exercise results in a progressive increase in the number of beta-adrenergic receptors on lymphocyte membranes, followed by a reduction in the density of receptors during the recovery phase of exercise. Despite a significant increase in the level of plasma catecholamines, the receptor remains coupled to the guanine nucleotide-binding regulatory protein.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. Schaller, D. Mechau, H. G. Scharmann, M. Weiss, M. Baum, and H. Liesen
Increased training load and the beta -adrenergic-receptor system on human lymphocytes
J Appl Physiol, July 1, 1999; 87(1): 317 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Fujii, S. Homma, F. Yamazaki, R. Sone, T. Shibata, H. Ikegami, K. Murakami, and H. Miyazaki
beta -Adrenergic receptor number in human lymphocytes is inversely correlated with aerobic capacity
Am J Physiol Endocrinol Metab, June 1, 1998; 274(6): E1106 - E1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Fujii, T. Shibata, S. Homma, H. Ikegami, K. Murakami, and H. Miyazaki
Exercise-induced changes in beta -adrenergic-receptor mRNA level measured by competitive RT-PCR
J Appl Physiol, June 1, 1997; 82(6): 1926 - 1931.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online