| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 66, Issue 2 704-711, Copyright © 1989 by American Physiological Society
ARTICLES |
K. J. Mikines, B. Sonne, B. Tronier and H. Galbo
Department of Medical Physiology B, Panum Institute, University of Copenhagen, Denmark.
Seven endurance-trained subjects [maximal O2 consumption (VO2max) 64 +/- 1 (SE) ml.min-1.kg-1] underwent sequential hyperinsulinemic euglycemic clamps on three occasions: 1) in the "habitual state" 15 h after the last training bout (C), 2) after 60 min of bicycle exercise at 72 +/- 3% of VO2max performed in the habitual state (E), and 3) 5 days after the last ordinary training session (detrained, DT). Sensitivity for insulin-mediated whole-body glucose uptake was not affected by acute exercise [insulin concentrations eliciting 50% of maximal insulin-mediated glucose uptake being 44 +/- 2 (C) vs. 46 +/- 3 (E) microU/ml] but was decreased after detraining (54 +/- 2 microU/ml, P less than 0.05) to levels comparable to those found in untrained subjects [Am. J. Physiol. 254 (Endocrinol. Metab. 17): E248-E259, 1988]. Near-maximal insulin-mediated glucose uptake (responsiveness) was higher than in untrained subjects and not influenced by acute exercise or detraining [13.4 +/- 1.2 (C), 12.2 +/- 0.9 (E), and 12.2 +/- 0.3 (DT) mg.min-1.kg-1]. Calculated by indirect calorimetry, the glucose-to-glycogen conversion was not influenced by E but was reduced during detraining (P less than 0.05) yet remained higher than previously found in untrained subjects (P less than 0.05). However, only on E days did muscle glycogen increase during insulin infusion. Glycogen synthase activity was increased on E and decreased on DT compared with C days.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  S. Fujita, B. B. Rasmussen, J. G. Cadenas, M. J. Drummond, E. L. Glynn, F. R. Sattler, and E. Volpi Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling Diabetes, June 1, 2007; 56(6): 1615 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Campbell and A. McTiernan Exercise and Biomarkers for Cancer Prevention Studies J. Nutr., January 1, 2007; 137(1): 161S - 169S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Bazzano, M. Serdula, and S. Liu Prevention of Type 2 Diabetes by Diet and Lifestyle Modification J. Am. Coll. Nutr., October 1, 2005; 24(5): 310 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S Kump and F. W Booth Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise J. Physiol., February 1, 2005; 562(3): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Frosig, S. B. Jorgensen, D. G. Hardie, E. A. Richter, and J. F. P. Wojtaszewski 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E411 - E417. [Abstract] [Full Text]
|
|
|
|
|
|
S. R. Stannard and N. A. Johnson Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty' genes? J. Physiol., February 1, 2004; 554(3): 595 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Goforth Jr., D. Laurent, W. K. Prusaczyk, K. E. Schneider, K. F. Petersen, and G. I. Shulman Effects of depletion exercise and light training on muscle glycogen supercompensation in men Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1304 - E1311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Gan, A. D. Kriketos, B. A. Ellis, C. H. Thompson, E. W. Kraegen, and D. J. Chisholm Changes in Aerobic Capacity and Visceral Fat but not Myocyte Lipid Levels Predict Increased Insulin Action After Exercise in Overweight and Obese Men Diabetes Care, June 1, 2003; 26(6): 1706 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J.O. Joseph, T. A. Trappe, P. A. Farrell, W. W. Campbell, K. E. Yarasheski, C. P. Lambert, and W. J. Evans Short-Term Moderate Weight Loss and Resistance Training Do Not Affect Insulin-Stimulated Glucose Disposal in Postmenopausal Women Diabetes Care, November 1, 2001; 24(11): 1863 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Rose, K. Howlett, D. S. King, and M. Hargreaves Effect of prior exercise on glucose metabolism in trained men Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E766 - E771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Ryan, D. C. Muller, and D. Elahi Sequential hyperglycemic-euglycemic clamp to assess {beta}-cell and peripheral tissue: studies in female athletes J Appl Physiol, August 1, 2001; 91(2): 872 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Toth, C. K. Sites, W. T. Cefalu, D. E. Matthews, and E. T. Poehlman Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E113 - E121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Blumenthal, A. Sherwood, E. C. D. Gullette, M. Babyak, R. Waugh, A. Georgiades, L. W. Craighead, D. Tweedy, M. Feinglos, M. Appelbaum, et al. Exercise and Weight Loss Reduce Blood Pressure in Men and Women With Mild Hypertension: Effects on Cardiovascular, Metabolic, and Hemodynamic Functioning Arch Intern Med, July 10, 2000; 160(13): 1947 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Kirwan, L. F. del Aguila, J. M. Hernandez, D. L. Williamson, D. J. O'Gorman, R. Lewis, and R. K. Krishnan Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle J Appl Physiol, February 1, 2000; 88(2): 797 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Chibalin, M. Yu, J. W. Ryder, X. M. Song, D. Galuska, A. Krook, H. Wallberg-Henriksson, and J. R. Zierath Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2 PNAS, January 4, 2000; 97(1): 38 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dela, K. J. Mikines, J. J. Larsen, and H. Galbo Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise J Appl Physiol, December 1, 1999; 87(6): 2059 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Koval, R. A. DeFronzo, R. M. O'Doherty, R. Printz, H. Ardehali, D. K. Granner, and L. J. Mandarino Regulation of hexokinase II activity and expression in human muscle by moderate exercise Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E304 - E308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawanaka, I. Tabata, S. Katsuta, and M. Higuchi Changes in insulin-stimulated glucose transport and GLUT-4 protein in rat skeletal muscle after training J Appl Physiol, December 1, 1997; 83(6): 2043 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perseghin, T. B. Price, K. F. Petersen, M. Roden, G. W. Cline, K. Gerow, D. L. Rothman, and G. I. Shulman Increased Glucose Transport-Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects N. Engl. J. Med., October 31, 1996; 335(18): 1357 - 1362. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
