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J Appl Physiol 66: 1003-1007, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 66, Issue 2 1003-1007, Copyright © 1989 by American Physiological Society

ARTICLES

Cytokines increase rat lung antioxidant enzymes during exposure to hyperoxia

C. W. White, P. Ghezzi, S. McMahon, C. A. Dinarello and J. E. Repine
Department of Pediatrics, Webb-Waring Lung Institute, Children's Hospital, Denver, Colorado 80262.

Pretreatment with the combination of tumor necrosis factor/cachectin (TNF/C) and interleukin 1 (IL-1) increased glucose-6-phosphate dehydrogenase (G6PDH), glutathione reductase (GR), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) activities in lungs of rats continuously exposed to hyperoxia for 72 h, a time when all untreated rats had already died. Pretreatment with TNF/C and IL-1 also increased, albeit slightly, lung G6PDH and GR activities of rats exposed to hyperoxia for 4 or 16 h. By comparison, no differences occurred in lung antioxidant enzyme activities of TNF/C and IL-1- or saline-pretreated rats exposed to hyperoxia for 36 or 52 h; the latter is a time just before untreated rats began to succumb during exposure to hyperoxia. The results raise the possibility that TNF/C and IL-1 treatment can increase lung antioxidant enzyme activities and that increased lung antioxidant enzymes may contribute to the increased survival of TNF/C and IL-1-pretreated rats in hyperoxia for greater than 72 h.


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