Journal of Applied Physiology
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J Appl Physiol 66: 504-508, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 66, Issue 1 504-508, Copyright © 1989 by American Physiological Society

ARTICLES

Adrenergic stimulation of inositol phosphate accumulation in tracheal epithelium

T. Bainbridge, R. D. Feldman and M. J. Welsh
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.

To determine whether inositol phosphates are important second messengers in the regulation of Cl- secretion by airway epithelia, we examined the relationship between inositol phosphate accumulation and Cl- secretion in response to adrenergic agonists. We found that epinephrine stimulated Cl- secretion and inositol phosphate accumulation with similar concentration dependence. Although isoproterenol stimulated Cl- secretion, there was no effect of beta-adrenergic receptor activation on inositol phosphate accumulation. In contrast, alpha 1-adrenergic receptor activation stimulated inositol phosphate accumulation but failed to induce Cl- secretion. Another Cl- secretagogue, prostaglandin E1, also failed to stimulate inositol phosphate accumulation. These data suggest that inositol phosphate accumulation is neither sufficient nor required for stimulation of Cl- secretion in cultured canine tracheal epithelial cells.




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