Journal of Applied Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 66: 429-436, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sinoway, L.
Right arrow Articles by Zelis, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sinoway, L.
Right arrow Articles by Zelis, R.

Journal of Applied Physiology, Vol 66, Issue 1 429-436, Copyright © 1989 by American Physiological Society

ARTICLES

Muscle acidosis during static exercise is associated with calf vasoconstriction

L. Sinoway, S. Prophet, I. Gorman, T. Mosher, J. Shenberger, M. Dolecki, R. Briggs and R. Zelis
Department of Medicine and Radiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

In this study we measured (n = 6) the phosphocreatine-to-inorganic phosphate ratio (PCr/Pi), Pi, and pH with 31P-nuclear magnetic resonance (31P-NMR) in the human forearm during static work at 30% of maximal voluntary contraction (MVC) for 2 min followed immediately by 3 min of circulatory arrest (forearm arterial occlusion). Static exercise, with its central volitional and skeletal muscle metabolic and mechanical afferent components, caused a rise in heart rate (HR, 32%), blood pressure (BP, 29%), and calf vascular resistance (calf R, 30%). During forearm occlusion after static exercise, HR returned to base line, the increase in BP was attenuated by 30%, and calf R remained elevated and unchanged. The percent change in calf R was correlated with forearm cellular pH (R = 0.56, P less than 0.001) but only weakly associated with PCr/Pi (R = 0.33, P less than 0.042). 30% MVC for 1 min followed by arterial occlusion (3 min) reduced PCr/Pi by 65% and pH by 0.16 U (P less than 0.05). Calf R was unchanged. Circulatory arrest alone (20 min) caused no change in either pH or calf R but large changes in PCr/Pi (50% reduction). We conclude that 1) there is an association between forearm cellular acidosis and calf vasconstriction during static forearm exercise and 2) large changes in PCr/Pi without concomitant changes in pH are not associated with changes in calf R.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. R. Light, R. W. Hughen, J. Zhang, J. Rainier, Z. Liu, and J. Lee
Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1
J Neurophysiol, September 1, 2008; 100(3): 1184 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Xing, Z. Gao, J. Lu, L. I. Sinoway, and J. Li
Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1262 - H1269.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Xing, L. Sinoway, and J. Li
Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin
J. Physiol., July 1, 2008; 586(13): 3245 - 3252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Cui, V. Mascarenhas, R. Moradkhan, C. Blaha, and L. I. Sinoway
Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R458 - R466.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Ogoh, J. P. Fisher, P. B. Raven, and P. J. Fadel
Arterial baroreflex control of muscle sympathetic nerve activity in the transition from rest to steady-state dynamic exercise in humans
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2202 - H2209.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. K. Pellinger and J. R. Halliwill
Effect of propranolol on sympathetically mediated leg vasoconstriction in humans
J. Physiol., September 1, 2007; 583(2): 797 - 809.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Cui, P. McQuillan, A. Momen, C. Blaha, R. Moradkhan, V. Mascarenhas, C. Hogeman, A. Krishnan, and L. I. Sinoway
The role of the cyclooxygenase products in evoking sympathetic activation in exercise
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1861 - H1868.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. G. Hayes, A. E. Kindig, and M. P. Kaufman
Blockade of acid sensing ion channels attenuates the exercise pressor reflex in cats
J. Physiol., June 15, 2007; 581(3): 1271 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Gao, J. D. Li, L. I. Sinoway, and J. Li
Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response
J Appl Physiol, June 1, 2007; 102(6): 2288 - 2293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Morelot-Panzini, A. Demoule, C. Straus, M. Zelter, J.-P. Derenne, J.-C. Willer, and T. Similowski
Dyspnea as a Noxious Sensation: Inspiratory Threshold Loading May Trigger Diffuse Noxious Inhibitory Controls in Humans
J Neurophysiol, February 1, 2007; 97(2): 1396 - 1404.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. E. Kindig, S. G. Hayes, and M. P. Kaufman
Purinergic 2 receptor blockade prevents the responses of group IV afferents to post-contraction circulatory occlusion
J. Physiol., January 1, 2007; 578(1): 301 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. P. Kaufman
Mechanoreceptors and central command
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H117 - H118.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Cui, C. Blaha, R. Moradkhan, K. S. Gray, and L. I. Sinoway
Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans
J. Physiol., October 15, 2006; 576(2): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Gao, V. Kehoe, J. Xing, L. Sinoway, and J. Li
Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1255 - H1261.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. P. Fisher, S. Ogoh, E. A. Dawson, P. J. Fadel, N. H. Secher, P. B. Raven, and M. J. White
Cardiac and vasomotor components of the carotid baroreflex control of arterial blood pressure during isometric exercise in humans
J. Physiol., May 1, 2006; 572(3): 869 - 880.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. I. Sinoway and J. Li
A perspective on the muscle reflex: implications for congestive heart failure
J Appl Physiol, July 1, 2005; 99(1): 5 - 22.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Li, N. C. King, and L. I. Sinoway
Interstitial ATP and Norepinephrine Concentrations in Active Muscle
Circulation, May 31, 2005; 111(21): 2748 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. A. Smith, M. A. Williams, J. H. Mitchell, P. P.A. Mammen, and M. G. Garry
The Capsaicin-Sensitive Afferent Neuron in Skeletal Muscle Is Abnormal in Heart Failure
Circulation, April 26, 2005; 111(16): 2056 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Houssiere, B. Najem, A. Ciarka, S. Velez-Roa, R. Naeije, and P. van de Borne
Chemoreflex and metaboreflex control during static hypoxic exercise
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1724 - H1729.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Kindig, T. B. Heller, and M. P. Kaufman
VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1867 - H1873.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Li, A. N. Sinoway, Z. Gao, M. D. Maile, M. Pu, and L. I. Sinoway
Muscle Mechanoreflex and Metaboreflex Responses After Myocardial Infarction in Rats
Circulation, November 9, 2004; 110(19): 3049 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Mizuno, K. Tokizawa, T. Iwakawa, and I. Muraoka
Inflection points of cardiovascular responses and oxygenation are correlated in the distal but not the proximal portions of muscle during incremental exercise
J Appl Physiol, September 1, 2004; 97(3): 867 - 873.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Marqueste, J.-R. Alliez, O. Alluin, Y. Jammes, and P. Decherchi
Neuromuscular rehabilitation by treadmill running or electrical stimulation after peripheral nerve injury and repair
J Appl Physiol, May 1, 2004; 96(5): 1988 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Hanna and M. P. Kaufman
Activation of thin-fiber muscle afferents by a P2X agonist in cats
J Appl Physiol, March 1, 2004; 96(3): 1166 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Tokizawa, M. Mizuno, Y. Nakamura, and I. Muraoka
Venous occlusion to the lower limb attenuates vasoconstriction in the nonexercised limb during posthandgrip muscle ischemia
J Appl Physiol, March 1, 2004; 96(3): 981 - 984.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
U. A. Leuenberger, S. Mostoufi-Moab, M. Herr, K. Gray, A. Kunselman, and L. I. Sinoway
Control of Skin Sympathetic Nerve Activity During Intermittent Static Handgrip Exercise
Circulation, November 11, 2003; 108(19): 2329 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Daley III, M. H. Khan, C. S. Hogeman, and L. I. Sinoway
Autonomic and vascular responses to reduced limb perfusion
J Appl Physiol, October 1, 2003; 95(4): 1493 - 1498.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. R. Rodman, K. S. Henderson, C. A. Smith, and J. A. Dempsey
Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise
J Appl Physiol, September 1, 2003; 95(3): 1159 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Hanna and M. P. Kaufman
Role played by purinergic receptors on muscle afferents in evoking the exercise pressor reflex
J Appl Physiol, April 1, 2003; 94(4): 1437 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Hanna, S. G. Hayes, and M. P. Kaufman
alpha ,beta -Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats
J Appl Physiol, September 1, 2002; 93(3): 834 - 841.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Daley III, C. S. Hogeman, and L. I. Sinoway
Venous plasma potassium is not associated with maintenance of the exercise pressor reflex in humans
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1608 - R1612.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. G. Hayes and M. P. Kaufman
MLR stimulation and exercise pressor reflex activate different renal sympathetic fibers in decerebrate cats
J Appl Physiol, April 1, 2002; 92(4): 1628 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Lee, J. K. Shoemaker, P. M. McQuillan, A. R. Kunselman, M. B. Smith, Q. X. Yang, H. Smith, K. Gray, and L. I. Sinoway
Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H586 - H593.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Kondo, H. Tominaga, M. Shibasaki, K. Aoki, S. Okada, and T. Nishiyasu
Effects of exercise intensity on the sweating response to a sustained static exercise
J Appl Physiol, May 1, 2000; 88(5): 1590 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. V. Ng, H. T. Dao, R. G. Miller, D. F. Gelinas, and J. A. Kent-Braun
Blunted pressor and intramuscular metabolic responses to voluntary isometric exercise in multiple sclerosis
J Appl Physiol, March 1, 2000; 88(3): 871 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. MacLean, V. A. Imadojemu, and L. I. Sinoway
Interstitial pH, K+, lactate, and phosphate determined with MSNA during exercise in humans
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R563 - R571.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Pavia, J. Myers, and R. Cesare
Recovery Kinetics of Oxygen Uptake and Heart Rate in Patients With Coronary Artery Disease and Heart Failure
Chest, September 1, 1999; 116(3): 808 - 813.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Herr, V. Imadojemu, A. R. Kunselman, and L. I. Sinoway
Characteristics of the muscle mechanoreflex during quadriceps contractions in humans
J Appl Physiol, February 1, 1999; 86(2): 767 - 772.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. D. Sheriff, R. A. Augustyniak, and D. S. O'Leary
Muscle chemoreflex-induced increases in right atrial pressure
Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H767 - H775.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. H. Silber, G. Sutliff, Q. X. Yang, M. B. Smith, L. I. Sinoway, and U. A. Leuenberger
Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure
J Appl Physiol, May 1, 1998; 84(5): 1551 - 1559.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Nishiyasu, N. Tan, K. Morimoto, R. Sone, and N. Murakami
Cardiovascular and humoral responses to sustained muscle metaboreflex activation in humans
J Appl Physiol, January 1, 1998; 84(1): 116 - 122.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Mostoufi-Moab, E. J. Widmaier, J. A. Cornett, K. Gray, and L. I. Sinoway
Forearm training reduces the exercise pressor reflex during ischemic rhythmic handgrip
J Appl Physiol, January 1, 1998; 84(1): 277 - 283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Ray, K. M. Hume, K. H. Gracey, and E. T. Mahoney
Muscle cooling delays activation of the muscle metaboreflex in humans
Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2436 - H2441.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Ray and K. H. Gracey
Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating
J Appl Physiol, June 1, 1997; 82(6): 1719 - 1733.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Cohen-Solal, T. Laperche, D. Morvan, M. Geneves, B. Caviezel, and R. Gourgon
Prolonged Kinetics of Recovery of Oxygen Consumption After Maximal Graded Exercise in Patients With Chronic Heart Failure : Analysis With Gas Exchange Measurements and NMR Spectroscopy
Circulation, June 15, 1995; 91(12): 2924 - 2932.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
R. G. Victor, N. H. Secher, T. Lyson, and J. H. Mitchell
Central Command Increases Muscle Sympathetic Nerve Activity During Intense Intermittent Isometric Exercise in Humans
Circ. Res., January 1, 1995; 76(1): 127 - 131.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online