Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol 66: 184-189, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 66, Issue 1 184-189, Copyright © 1989 by American Physiological Society

ARTICLES

Cardiovascular failure and apnea in shock

S. Nava and F. Bellemare
Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.

A model of shock was developed in anesthetized dogs by limiting venous return with a balloon inflated in the right atrium. The change in ventilation (VE) in response to a sustained decrease in arterial pressure (Pa) to 50-60 Torr was studied by recording transdiaphragmatic pressure (Pdi) and diaphragm (Edi) and parasternal intercostal (Eic) electrical activity. Four dogs died of cardiac arrest after 20-60 min. In 11 dogs, VE, after an initial increase, decreased progressively until apnea occurred after 103 +/- 24 min, after 60% reductions in breathing frequency, Pdi, and Eic and a 30% fall in Edi. No decrease in diaphragm contractility was found in response to artificial phrenic nerve stimulation. The cardiocirculatory function deteriorated during shock until it became irreversible at apneic time. No recovery from apnea occurred without a recovery of Pa. We conclude that the fall in VE and ensuing apnea in this model resulted from a decrease in central respiratory neural output associated with a progressive deterioration of the cardiocirculatory function.


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