Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 65: 2679-2686, 1988;
8750-7587/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kariya, S. T.
Right arrow Articles by Drazen, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kariya, S. T.
Right arrow Articles by Drazen, J. M.

Journal of Applied Physiology, Vol 65, Issue 6 2679-2686, Copyright © 1988 by American Physiological Society

ARTICLES

Methacholine-induced bronchoconstriction in dogs: effects of lung volume and O3 exposure

S. T. Kariya, S. A. Shore, W. A. Skornik, K. Anderson, R. H. Ingram Jr and J. M. Drazen
Department of Environmental Sciences and Physiology, Harvard School of Public Health, Boston, Massachusetts.

The maximal effect induced by methacholine (MCh) aerosols on pulmonary resistance (RL), and the effects of altering lung volume and O3 exposure on these induced changes in RL, was studied in five anesthetized and paralyzed dogs. RL was measured at functional residual capacity (FRC), and lung volumes above and below FRC, after exposure to MCh aerosols generated from solutions of 0.1-300 mg MCh/ml. The relative site of response was examined by magnifying parenchymal [RL with large tidal volume (VT) at fast frequency (RLLS)] or airway effects [RL with small VT at fast frequency (RLSF)]. Measurements were performed on dogs before and after 2 h of exposure to 3 ppm O3. MCh concentration-response curves for both RLLS and RLSF were sigmoid shaped. Alterations in mean lung volume did not alter RLLS; however, RLSF was larger below FRC than at higher lung volumes. Although O3 exposure resulted in small leftward shifts of the concentration-response curve for RLLS, the airway dominated index of RL (RLSF) was not altered by O3 exposure, nor was the maximal response using either index of RL. These data suggest O3 exposure does not affect MCh responses in conducting airways; rather, it affects responses of peripheral contractile elements to MCh, without changing their maximal response.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
R. FRANK, M. C. LIU, E. W. SPANNHAKE, S. MLYNAREK, K. MACRI, and G. G. WEINMANN
Repetitive Ozone Exposure of Young Adults . Evidence of Persistent Small Airway Dysfunction
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1253 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. H. Brown and W. Mitzner
The myth of maximal airway responsiveness in vivo
J Appl Physiol, December 1, 1998; 85(6): 2012 - 2017.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. H. BROWN, J. GEORGAKOPOULOS, and W. MITZNER
Individual Canine Airways Responsiveness to Aerosol Histamine and Methacholine in Vivo
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 491 - 497.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online