Journal of Applied Physiology
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J Appl Physiol 65: 1938-1943, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 5 1938-1943, Copyright © 1988 by American Physiological Society

ARTICLES

Characteristics of tachyphylaxis to inhaled histamine in anesthetized dogs

P. J. Antol, M. Fujita and R. E. Hyatt
Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Three consecutive dose-response curves to aerosolized histamine were obtained in 11 anesthetized dogs. All dogs showed desensitization (i.e., tachyphylaxis) to high doses of histamine. Tachyphylaxis was highly reproducible. No tachyphylaxis occurred with inhaled acetylcholine or methacholine. Beta-Adrenergic blockade with propranolol or muscarinic blockade with atropine given intravenously had no effect on the histamine tachyphylaxis. Duration of thiamylal anesthesia did not alter the histamine responsiveness. Histamine tachyphylaxis was also seen with chloralose-urethan anesthesia. Since tachyphylaxis is not observed with acetylcholine, it cannot be attributed to a general decline in muscle contractility. We conclude that histamine tachyphylaxis in vivo is not explained by effects of cholinergic reflexes, catecholamine release, duration of anesthesia, or, probably, type of anesthetic agent.


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