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J Appl Physiol 65: 1203-1209, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 3 1203-1209, Copyright © 1988 by American Physiological Society

ARTICLES

Mucus transport by high-frequency nonsymmetrical oscillatory airflow

H. K. Chang, M. E. Weber and M. King
Department of Biomedical Engineering, University of Southern California, Los Angeles 90089-1451.

To study air-mucus interaction as a possible mechanism of tracheal mucus transport and to test the validity of using surface tracer displacement to indicate bulk mucus transport, we performed a combined experimental-theoretical study. We hypothesized that the mucus mass is moved by the difference between expiratory and inspiratory velocities. The rate of transport of a layer of simulated mucus lining the bottom of a rectangular trough was measured in two ways during oscillatory air flow. Peak velocity ratios (R) from 1.0 to 2.0, frequencies (f) between 7 and 13 Hz, and tidal volumes (VT) between 50 and 100 ml were generated by a custom-made pump. The experimental results demonstrate that measuring the displacement of a tracer deposited on the surface of the mucus layer is equivalent to measuring bulk mucus movement by weight. Moreover the measured mucus velocities (micron) correlate well with a theoretical model which predicts that micron is proportional to delta VT f1.5 (R-1). These results suggest that shearing at the air-mucus interface could be a significant factor in the enhanced tracheal mucus clearance during high-frequency chest wall oscillation.


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