Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 65: 1069-1074, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 3 1069-1074, Copyright © 1988 by American Physiological Society

ARTICLES

Respiratory reflex responses to stimulation of tracheal mucosa in enflurane-anesthetized humans

T. Nishino, K. Hiraga, T. Mizuguchi and Y. Honda
Department of Anesthesiology, National Cancer Center Hospital, Tokyo, Japan.

We investigated respiratory reflex responses to tracheal mucosa stimulation induced by injection of distilled water in 13 female patients under three different depths of enflurane anesthesia (0.7, 1.0, and 1.3 minimum alveolar concentration). Detailed analysis of the types of reflex responses revealed that there are at least six different responses: 1) the apneic reflex, 2) the expiration reflex, 3) spasmodic, panting breathing, 4) the cough reflex, 5) slowing of breathing, and 6) rapid, shallow breathing. Among these reflex responses, the cough reflex was the most sensitive and the apneic reflex followed by slowing of breathing was the most resistant to deepening anesthesia, whereas the sensitivity of other types of reflex responses was in between. Our results indicate that the types of respiratory reflex responses to tracheal mucosa stimulation are associated with depths of anesthesia and that the differences in sensitivity to anesthesia may be a valuable sign in clinical assessment of depth of anesthesia.


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