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J Appl Physiol 65: 1050-1054, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 3 1050-1054, Copyright © 1988 by American Physiological Society

ARTICLES

Depression of hypoxic ventilatory response in humans by somatostatin

R. B. Filuk, D. J. Berezanski and N. R. Anthonisen
Respiratory Investigation Unit, University of Manitoba, Winnipeg, Canada.

In nine normal subjects we measured the ventilatory response to isocapnic hypoxia with and without an intravenous infusion of 1 mg of somatostatin. Arterial O2 saturation was rapidly lowered to 80 +/- 2% in 2 min and maintained for 30 min. During control experiments, ventilation increased immediately (3-5 min) and then declined so that at 25 min of hypoxia ventilation was little above that in room air. Somatostatin was associated with a small decrease in ventilation while the subjects breathed room air. With hypoxia there was no immediate increase in ventilation for the group as a whole, although an increase was observed in one subject. With somatostatin, after 25 min of hypoxia, mean ventilation was lower than at any other time in the study; as hypoxia was discontinued ventilation increased slightly. Somatostatin causes profound depression of the ventilatory response to hypoxia by a mechanism that is not known but may be central. With somatostatin hypoxia of 25-min duration tends to depress ventilation.


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J. J. Pandit, D. Sjogren, S. G. E. Lindahl, and A. Sollevi
Hypoxic ventilatory response: the effects of CO2 and of sustained hypoxia.
Anesth. Analg., March 1, 1999; 88(3): 695 - 696.
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