Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 65: 1050-1054, 1988;
8750-7587/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Filuk, R. B.
Right arrow Articles by Anthonisen, N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Filuk, R. B.
Right arrow Articles by Anthonisen, N. R.

Journal of Applied Physiology, Vol 65, Issue 3 1050-1054, Copyright © 1988 by American Physiological Society

ARTICLES

Depression of hypoxic ventilatory response in humans by somatostatin

R. B. Filuk, D. J. Berezanski and N. R. Anthonisen
Respiratory Investigation Unit, University of Manitoba, Winnipeg, Canada.

In nine normal subjects we measured the ventilatory response to isocapnic hypoxia with and without an intravenous infusion of 1 mg of somatostatin. Arterial O2 saturation was rapidly lowered to 80 +/- 2% in 2 min and maintained for 30 min. During control experiments, ventilation increased immediately (3-5 min) and then declined so that at 25 min of hypoxia ventilation was little above that in room air. Somatostatin was associated with a small decrease in ventilation while the subjects breathed room air. With hypoxia there was no immediate increase in ventilation for the group as a whole, although an increase was observed in one subject. With somatostatin, after 25 min of hypoxia, mean ventilation was lower than at any other time in the study; as hypoxia was discontinued ventilation increased slightly. Somatostatin causes profound depression of the ventilatory response to hypoxia by a mechanism that is not known but may be central. With somatostatin hypoxia of 25-min duration tends to depress ventilation.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
M. E F Pedersen, K. L Dorrington, and P. A Robbins
Effects of somatostatin on the control of breathing in humans
J. Physiol., November 15, 1999; 521(1): 289 - 297.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. J. Pandit, D. Sjogren, S. G. E. Lindahl, and A. Sollevi
Hypoxic ventilatory response: the effects of CO2 and of sustained hypoxia.
Anesth. Analg., March 1, 1999; 88(3): 695 - 696.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online