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J Appl Physiol 65: 1040-1044, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 3 1040-1044, Copyright © 1988 by American Physiological Society

ARTICLES

Comparison of diaphragmatic fatigue in newborn and older rabbits

P. N. Le Souef, S. J. England, H. A. Stogryn and A. C. Bryan
Department of Respiratory Physiology, Hospital for Sick Children, Toronto, Ontario, Canada.

The ability to maintain occlusion pressure (i.e., fatigability) during activation of the diaphragm via phrenic nerve stimulation was compared in newborn (less than 14 days old) and older (greater than 30 days old) rabbits. The younger animals had lower maximum inspiratory pressures (MIP) and markedly greater falls in pressure during sustained diaphragmatic contractions at greater than 40% MIP than did the older animals. Histological analysis showed a paucity of high-oxidative type I fibers in the diaphragms of the young animals. We therefore conclude that the newborn rabbit diaphragm is extremely susceptible to fatigue and that this susceptibility correlates with the distribution of muscle fiber types.


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