Journal of Applied Physiology, Vol 65, Issue 3 1024-1032, Copyright © 1988 by American Physiological Society
Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis
A. G. Gnidec, W. J. Sibbald, H. Cheung and C. A. Metz
Richard Ivey Critical Care Trauma Centre, Victoria Hospital, London, Ontario, Canada.
Since severity of acute lung injury (ALI) is reduced by pretreatment with
non-steroidal agents, we hypothesized that ibuprofen would ameliorate ALI
when administered after the onset of septic lung injury. Twenty-four hours
after cecal ligation and perforation (CLP) in 23 sheep during a 4 h study
period (period S), pulmonary lymph flow (QL) increased 16.2 +/- 12.1 ml/min
(P less than 0.01) from base line, whereas lymph-to-plasma total protein
concentration ratios ([L/P]TP) remained unchanged. During the subsequent 24
h of study (period D), 10 sheep received parenteral ibuprofen, 12.5 mg/kg
every 6 h, and 13 sheep served as untreated septic controls. Throughout
period D, a progressive increase in QL (16.2 +/- 16.3 ml/60 min) from
period S was greater in the untreated than in the ibuprofen (2.5 +/- 9.0
ml/60 min, P less than 0.02) group. Between base line and period D,
increase in lung wet-to-dry weight ratios was greater in the untreated
group than in the ibuprofen group (P less than 0.05). Concurrently mean
pulmonary arterial pressure increased 4.7 +/- 7.3 mmHg in the untreated
group (P less than 0.05) during period D vs. 0.0 +/- 5.2 mmHg in the
ibuprofen group (NS). When administered after septic ALI had been
established by CLP, ibuprofen reduced an otherwise progressive increase in
both fluid flux and extravascular lung water.
