Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 65: 669-674, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 65, Issue 2 669-674, Copyright © 1988 by American Physiological Society

ARTICLES

Noninvasive diffusing capacity and cardiac output in exercising dogs

J. I. Carlin, S. S. Cassidy, U. Rajagopal, P. S. Clifford and R. L. Johnson Jr
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.

We have developed a rebreathing procedure to determine diffusing capacity (DLCO) and pulmonary blood flow (Qc) in the awake, exercising dog. A low dead space, leak-free respiratory mask with an incorporated mouthpiece was utilized to achieve mixing between the rebreathing bag and the dog's lung. The rebreathing bag was initially filled with approximately 1.0 liter of gas containing 0.6% C2H2, 0.3% C18O, 9% He, and 35-40% O2. End-tidal gas concentrations were measured with a respiratory mass spectrometer. The disappearance of C2H2 and C18O was measured with respect to He to calculate Qc and DLCO. Values for DLCO in dogs, expressed per kilogram of body weight, were much larger than those reported in humans. However, at a given level of absolute O2 consumption, measurements of absolute DLCO in dogs were comparable to those reported in humans by both rebreathing and steady-state methods at rest and near-maximal exercise. These results suggest that DLCO is more closely matched to the metabolic capacity (i.e., maximal O2 consumption) than to body size between these two species.


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