Journal of Applied Physiology, Vol 65, Issue 1 46-52, Copyright © 1988 by American Physiological Society

ARTICLES

Effect of alveolar hypoxia on pulmonary fluid filtration in in situ dog lungs

L. A. Homik, Z. Bshouty, R. B. Light and M. Younes
Respiratory Investigation Unit, University of Manitoba, Winnipeg, Canada.

We have studied the effect of alveolar hypoxia on fluid filtration characteristics of the pulmonary microcirculation in an in situ left upper lobe preparation with near static flow conditions (20 ml/min). In six dogs (group 1), rate of edema formation (delta W/delta t, where W is weight and t is time) was assessed over a wide range of vascular pressures under two inspired O2 fraction (FIO2) conditions (0.95 and 0.0 with 5% CO2-balance N2 in both cases). delta W/delta t was plotted against vascular pressure, and the best-fit linear regression was obtained. There was no significant difference (paired t test) in either threshold pressure for edema formation [18.3 +/- 1.8 and 17.1 +/- 1.2 (SE) mmHg, respectively] or the slopes (0.067 +/- 0.008 and 0.073 +/- 0.017 g.min-1. mmHg-1.100g-1, respectively). In another seven dogs (group 2), delta W/delta t was obtained at a constant vascular pressure of 40 mmHg under four FIO2 conditions (0.95, 0.21, 0.05, and 0.0, with 5% CO2-balance N2). Delta W/delta t for the four conditions averaged 0.60 +/- 0.11, 0.61 +/- 0.11, 0.61 +/- 0.10, and 0.61 +/- 0.10 (SE) g.min-1.mmHg-1.100g-1, respectively. No significant differences (ANOVA for repeated measures) were noted. We conclude that alveolar hypoxia does not alter the threshold for edema formation or delta W/delta t at a given microvascular pressure.

This article has been cited by other articles:

				E. M. Snyder, K. C. Beck, M. L. Hulsebus, J. F. Breen, E. A. Hoffman, and B. D. Johnson Short-term hypoxic exposure at rest and during exercise reduces lung water in healthy humans J Appl Physiol, December 1, 2006; 101(6): 1623 - 1632. [Abstract] [Full Text] [PDF]

				C. Dehnert, F. Risse, S. Ley, T. A. Kuder, R. Buhmann, M. Puderbach, E. Menold, D. Mereles, H.-U. Kauczor, P. Bartsch, et al. Magnetic Resonance Imaging of Uneven Pulmonary Perfusion in Hypoxia in Humans Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1132 - 1138. [Abstract] [Full Text] [PDF]

				M. Maggiorini High altitude-induced pulmonary oedema Cardiovasc Res, October 1, 2006; 72(1): 41 - 50. [Abstract] [Full Text] [PDF]

				P. Bartsch, H. Mairbaurl, M. Maggiorini, and E. R. Swenson Physiological aspects of high-altitude pulmonary edema J Appl Physiol, March 1, 2005; 98(3): 1101 - 1110. [Abstract] [Full Text] [PDF]

				E. R. Swenson, M. Maggiorini, S. Mongovin, J. S. R. Gibbs, I. Greve, H. Mairbaurl, and P. Bartsch Pathogenesis of High-Altitude Pulmonary Edema: Inflammation Is Not an Etiologic Factor JAMA, May 1, 2002; 287(17): 2228 - 2235. [Abstract] [Full Text] [PDF]

				M. Maggiorini, C. Melot, S. Pierre, F. Pfeiffer, I. Greve, C. Sartori, M. Lepori, M. Hauser, U. Scherrer, and R. Naeije High-Altitude Pulmonary Edema Is Initially Caused by an Increase in Capillary Pressure Circulation, April 24, 2001; 103(16): 2078 - 2083. [Abstract] [Full Text] [PDF]