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J Appl Physiol 64: 2318-2323, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 64, Issue 6 2318-2323, Copyright © 1988 by American Physiological Society

ARTICLES

Pulmonary responses to bronchoconstrictor agonists in the mouse

T. R. Martin, N. P. Gerard, S. J. Galli and J. M. Drazen
Department of Pediatrics, Children's Hospital, Boston, Massachusetts 02215.

Mice have been used in studies of the immunology or pathology of several different disorders affecting the lung. However, the value of the mouse for the analysis of pulmonary pathophysiology has been limited by the lack of methods for measuring lung function in the living animal. We report here the first method for measuring pulmonary conductance (GL) and compliance (Cdyn) in tracheostomized mechanically ventilated mice. We used this method to characterize the mouse's pulmonary responses to several putative bronchoconstrictor agonists. GL and Cdyn were decreased by intravenous infusions of methacholine, norepinephrine, or serotonin. Reproducible responses were not detected after infusions of histamine, prostaglandins D2 or F2 alpha, leukotrienes C4 or D4, substance P, or platelet-activating factor. The pattern of airway responsiveness to these agonists in the mouse is similar to that reported for the rat; in contrast to the rat, the mouse has many well-characterized strains or mutants with deficiencies of immunologic or inflammatory cells or mediators. As a result, this model offers unique advantages for identifying the roles of individual inflammatory cell types or mediators in pulmonary processes, including pulmonary anaphylaxis.


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Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
J. Exp. Med., June 1, 1998; 187(11): 1779 - 1788.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
P. A. Padrid, M. Mathur, X. Li, K. Herrmann, Y. Qin, A. Cattamanchi, J. Weinstock, D. Elliott, A. I. Sperling, and J. A. Bluestone
CTLA4Ig Inhibits Airway Eosinophilia and Hyperresponsiveness by Regulating the Development of Th1/Th2 Subsets in a Murine Model of Asthma
Am. J. Respir. Cell Mol. Biol., April 1, 1998; 18(4): 453 - 462.
[Abstract] [Full Text]

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 Am. J. Respir. Crit. Care Med.Home page
A Haczku, K Takeda, E Hamelmann, A Oshiba, J Loader, A Joetham, C Irvin, H Kikutani, and E. Gelfand
CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin
Am. J. Respir. Crit. Care Med., December 1, 1997; 156(6): 1945 - 1955.
[Abstract] [Full Text]

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 Am. J. Respir. Crit. Care Med.Home page
T. NAGASE, S. ISHII, H. KATAYAMA, Y. FUKUCHI, Y. OUCHI, and T. SHIMIZU
Airway Responsiveness in Transgenic Mice Overexpressing Platelet-activating Factor Receptor . Roles of Thromboxanes and Leukotrienes
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1621 - 1627.
[Abstract] [Full Text]

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 Am. J. Respir. Crit. Care Med.Home page
G. T. DE SANCTIS and J. M. DRAZEN
Genetics of Native Airway Responsiveness in Mice
Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): S82 - S88.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
G. T. De Sanctis, W. W. Wolyniec, F. H. Y. Green, S. Qin, A. Jiao, P. W. Finn, T. Noonan, A. A. Joetham, E. Gelfand, C. M. Doerschuk, et al.
Reduction of allergic airway responses in P-selectin-deficient mice
J Appl Physiol, September 1, 1997; 83(3): 681 - 687.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
E. HAMELMANN, J. SCHWARZE, K. TAKEDA, A. OSHIBA, G. L. LARSEN, C. G. IRVIN, and E. W. GELFAND
Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 766 - 775.
[Abstract] [Full Text] [PDF]

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 JEMHome page
K. Takeda, E. Hamelmann, A. Joetham, L.D. Shultz, G.L. Larsen, C.G. Irvin, and E.W. Gelfand
Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell-deficient Mice
J. Exp. Med., August 4, 1997; 186(3): 449 - 454.
[Abstract] [Full Text] [PDF]

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 JEMHome page
H. Adler, J. L. Beland, N. C. Del-Pan, L. Kobzik, J. P. Brewer, T. R. Martin, and I. J. Rimm
Suppression of Herpes Simplex Virus Type 1 (HSV-1)-induced Pneumonia in Mice by Inhibition of Inducible Nitric Oxide Synthase (iNOS, NOS2)
J. Exp. Med., May 5, 1997; 185(9): 1533 - 1540.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
P. D. Mehlhop, M. van de Rijn, A. B. Goldberg, J. P. Brewer, V. P. Kurup, T. R. Martin, and H. C. Oettgen
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
PNAS, February 18, 1997; 94(4): 1344 - 1349.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
A. Maekawa, Y. Kanaoka, B. K. Lam, and K. F. Austen
Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing
PNAS, February 27, 2001; 98(5): 2256 - 2261.
[Abstract] [Full Text] [PDF]


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