| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 64, Issue 6 2306-2313, Copyright © 1988 by American Physiological Society
ARTICLES |
D. M. Rotto and M. P. Kaufman
Department of Physiology, University of Texas Health Science Center, Dallas 75235.
Static muscular contraction has been firmly established to reflexly increase cardiovascular and ventilatory function. Although group III and IV fibers with endings in muscle have been shown to comprise the afferent arm of this reflex arc, little is known about the nature of the contraction-induced stimulus causing the activation of these fibers. This stimulus has often been suggested to be a metabolic product of muscular contraction. We have therefore recorded the impulse activity of group III and IV afferents with endings in the triceps surae muscles of barbiturate-anesthetized cats while we injected into the femoral artery substances believed to be metabolic products of muscular contraction. We found that lithium and sodium lactate (400 mM; 1 ml) had little or no effect on the discharge of group III and IV afferents. Likewise, monobasic sodium phosphate (20 and 400 mM; 1 ml) and 2-chloroadenosine (50-100 micrograms) had only trivial effects on the discharge of these afferents. By contrast, lactic acid (25 and 400 mM; 1 ml) and arachidonic acid (0.5-2.0 mg) caused significant increases in the activity of group III and IV afferents. Most of the excitatory effect of arachidonic acid on the discharge of the afferents was prevented by indomethacin, a cyclooxygenase inhibitor. We conclude that of the substances tested in our experiments, lactic acid and some cyclooxygenase products, such as prostaglandins and thromboxanes, are the most likely to be responsible for any metabolic stimulation of group III and IV afferents during muscular contraction.
This article has been cited by other articles:
|
|
 |
|
  Z. Gao, S. Koba, L. Sinoway, and J. Li 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents J. Physiol., May 15, 2008; 586(10): 2581 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Abbiss, J. J. Peiffer, J. M. Peake, K. Nosaka, K. Suzuki, D. T. Martin, and P. B. Laursen Effect of carbohydrate ingestion and ambient temperature on muscle fatigue development in endurance-trained male cyclists J Appl Physiol, April 1, 2008; 104(4): 1021 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Drew, M. P. D. Bell, and M. J. White Modulation of spontaneous baroreflex control of heart rate and indexes of vagal tone by passive calf muscle stretch during graded metaboreflex activation in humans J Appl Physiol, March 1, 2008; 104(3): 716 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Taylor and S. C. Gandevia A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions J Appl Physiol, February 1, 2008; 104(2): 542 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, V. Mascarenhas, R. Moradkhan, C. Blaha, and L. I. Sinoway Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R458 - R466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amann and J. A. Dempsey Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance J. Physiol., January 1, 2008; 586(1): 161 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Houssiere, M. Gujic, G. Deboeck, A. Ciarka, R. Naeije, and P. van de Borne Increased metaboreflex activity is related to exercise intolerance in heart transplant patients Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3699 - H3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gujic, D. Laude, A. Houssiere, S. Beloka, J.-F. Argacha, D. Adamopoulos, O. Xhaet, J.-L. Elghozi, and P. van de Borne Differential effects of metaboreceptor and chemoreceptor activation on sympathetic and cardiac baroreflex control following exercise in hypoxia in human J. Physiol., November 15, 2007; 585(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Barry and R. M. Enoka The neurobiology of muscle fatigue: 15 years later Integr. Comp. Biol., October 1, 2007; 47(4): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Hayes, A. E. Kindig, and M. P. Kaufman Blockade of acid sensing ion channels attenuates the exercise pressor reflex in cats J. Physiol., June 15, 2007; 581(3): 1271 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Gao, J. D. Li, L. I. Sinoway, and J. Li Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response J Appl Physiol, June 1, 2007; 102(6): 2288 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amann, M. W. Eldridge, A. T. Lovering, M. K. Stickland, D. F. Pegelow, and J. A. Dempsey Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans J. Physiol., September 15, 2006; 575(3): 937 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Houssiere, B. Najem, N. Cuylits, S. Cuypers, R. Naeije, and P. van de Borne Hyperoxia enhances metaboreflex sensitivity during static exercise in humans Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H210 - H215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Hayes, A. E. Kindig, and M. P. Kaufman Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2239 - H2246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Iellamo, M. Di Rienzo, D. Lucini, J. M. Legramante, P. Pizzinelli, P. Castiglioni, F. Pigozzi, M. Pagani, and G. Parati Muscle metaboreflex contribution to cardiovascular regulation during dynamic exercise in microgravity: insights from mission STS-107 of the space shuttle Columbia J. Physiol., May 1, 2006; 572(3): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Babault, K. Desbrosses, M.-S. Fabre, A. Michaut, and M. Pousson Neuromuscular fatigue development during maximal concentric and isometric knee extensions J Appl Physiol, March 1, 2006; 100(3): 780 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kindig, S. G. Hayes, R. L. Hanna, and M. P. Kaufman P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1214 - H1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Sinoway and J. Li A perspective on the muscle reflex: implications for congestive heart failure J Appl Physiol, July 1, 2005; 99(1): 5 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kindig, T. B. Heller, and M. P. Kaufman VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1867 - H1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A St Clair Gibson and T D Noakes Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans Br. J. Sports Med., December 1, 2004; 38(6): 797 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, D. Bower, J. Boehmer, A. R. Kunselman, U. A. Leuenberger, and L. I. Sinoway Renal blood flow in heart failure patients during exercise Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2834 - H2839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Joyner Congestive Heart Failure: More Bad News From Exercising Muscle? Circulation, November 9, 2004; 110(19): 2978 - 2979. [Full Text] [PDF]
|
|
|
|
|
|
J. Li, M. D. Maile, A. N. Sinoway, and L. I. Sinoway Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel J Appl Physiol, November 1, 2004; 97(5): 1709 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Middlekauff, J. Chiu, M. A. Hamilton, G. C. Fonarow, W. R. MacLellan, A. Hage, J. Moriguchi, and J. Patel Muscle mechanoreceptor sensitivity in heart failure Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H1937 - H1943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, U. A. Leuenberger, B. Handly, and L. I. Sinoway Effect of aging on renal blood flow velocity during static exercise Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H735 - H740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Marqueste, J.-R. Alliez, O. Alluin, Y. Jammes, and P. Decherchi Neuromuscular rehabilitation by treadmill running or electrical stimulation after peripheral nerve injury and repair J Appl Physiol, May 1, 2004; 96(5): 1988 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hanna and M. P. Kaufman Activation of thin-fiber muscle afferents by a P2X agonist in cats J Appl Physiol, March 1, 2004; 96(3): 1166 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Haouzi, B. Chenuel, and A. Huszczuk Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control J Appl Physiol, February 1, 2004; 96(2): 407 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Rodman, K. S. Henderson, C. A. Smith, and J. A. Dempsey Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise J Appl Physiol, September 1, 2003; 95(3): 1159 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Russ and J. A. Kent-Braun Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions J Appl Physiol, June 1, 2003; 94(6): 2414 - 2422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Scott, R. Wensel, C. H. Davos, P. Georgiadou, M. Kemp, J. Hooper, A. J.S. Coats, and M. F. Piepoli Skeletal Muscle Reflex in Heart Failure Patients: Role of Hydrogen Circulation, January 21, 2003; 107(2): 300 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li and L. I. Sinoway ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2636 - H2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hanna, S. G. Hayes, and M. P. Kaufman alpha ,beta -Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats J Appl Physiol, September 1, 2002; 93(3): 834 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Scott, R. Wensel, C. H. Davos, M. Kemp, A. Kaczmarek, J. Hooper, A. J.S. Coats, and M. F. Piepoli Chemical Mediators of the Muscle Ergoreflex in Chronic Heart Failure: A Putative Role for Prostaglandins in Reflex Ventilatory Control Circulation, July 9, 2002; 106(2): 214 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Derchak, A. W. Sheel, B. J. Morgan, and J. A. Dempsey Effects of expiratory muscle work on muscle sympathetic nerve activity J Appl Physiol, April 1, 2002; 92(4): 1539 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Gandevia Spinal and Supraspinal Factors in Human Muscle Fatigue Physiol Rev, October 1, 2001; 81(4): 1725 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. J. Lott, C. S. Hogeman, L. Vickery, A. R. Kunselman, L. I. Sinoway, and D. A. MacLean Effects of dynamic exercise on mean blood velocity and muscle interstitial metabolite responses in humans Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1734 - H1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Notarius, D. J. Atchison, G. A. Rongen, and J. S. Floras Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1312 - H1318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Hayes and M. P. Kaufman Gadolinium attenuates exercise pressor reflex in cats Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2153 - H2161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Middlekauff, A. Doering, and J. N. Weiss Adenosine Enhances Neuroexcitability by Inhibiting a Slow Postspike Afterhyperpolarization in Rabbit Vagal Afferent Neurons Circulation, March 6, 2001; 103(9): 1325 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Notarius, D. J. Atchison, and J. S. Floras Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H969 - H976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Doerzbacher and C. A. Ray Muscle sympathetic nerve responses to physiological changes in prostaglandin production in humans J Appl Physiol, February 1, 2001; 90(2): 624 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. MacLean, L. M. Vickery, and L. I. Sinoway Elevated interstitial adenosine concentrations do not activate the muscle reflex Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H546 - H553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Leshnower, J. T. Potts, M. G. Garry, and J. H. Mitchell Reflex cardiovascular responses evoked by selective activation of skeletal muscle ergoreceptors J Appl Physiol, January 1, 2001; 90(1): 308 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. GOZAL and N. SIMAKAJORNBOON Passive Motion of the Extremities Modifies Alveolar Ventilation during Sleep in Patients with Congenital Central Hypoventilation Syndrome Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1747 - 1751. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. L. Jones and K. J. Killian Exercise Limitation in Health and Disease N. Engl. J. Med., August 31, 2000; 343(9): 632 - 641. [Full Text] [PDF]
|
|
|
|
|
|
S. Mostoufi-Moab, M. D. Herr, D. H. Silber, K. S. Gray, U. A. Leuenberger, and L. I. Sinoway Limb congestion enhances the synchronization of sympathetic outflow with muscle contraction Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R478 - R483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. MacLean, V. A. Imadojemu, and L. I. Sinoway Interstitial pH, K+, lactate, and phosphate determined with MSNA during exercise in humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R563 - R571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Middlekauff, E. U. Nitzsche, C. K. Hoh, M. A. Hamilton, G. C. Fonarow, A. Hage, and J. D. Moriguchi Exaggerated Renal Vasoconstriction During Exercise in Heart Failure Patients Circulation, February 22, 2000; 101(7): 784 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Haouzi, J. M. Hill, B. K. Lewis, and M. P. Kaufman Responses of group III and IV muscle afferents to distension of the peripheral vascular bed J Appl Physiol, August 1, 1999; 87(2): 545 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, H. D. Schultz, and R. Ma Cardiac sympathetic afferent sensitivity is enhanced in heart failure Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H812 - H817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Avela, H. Kyrolainen, and P. V. Komi Altered reflex sensitivity after repeated and prolonged passive muscle stretching J Appl Physiol, April 1, 1999; 86(4): 1283 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Avela, H. Kyrolainen, P. V. Komi, and D. Rama Reduced reflex sensitivity persists several days after long-lasting stretch-shortening cycle exercise J Appl Physiol, April 1, 1999; 86(4): 1292 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Laprad, R. A. Augustyniak, R. L. Hammond, and D. S. O'Leary Does gender influence the strength and mechanisms of the muscle metaboreflex during dynamic exercise in dogs? Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1203 - R1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. O'Leary, R. A. Augustyniak, E. J. Ansorge, and H. L. Collins Muscle metaboreflex improves O2 delivery to ischemic active skeletal muscle Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1399 - H1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Francis, A. Cohen-Solal, and D. Logeart Peripheral muscle ergoreceptors and ventilatory response during exercise recovery in heart failure Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H913 - H917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. MacLean, K. F. LaNoue, K. S. Gray, and L. I. Sinoway Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat J Appl Physiol, October 1, 1998; 85(4): 1583 - 1592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Thomas, B. Chavoshan, M. Sander, and R. G. Victor Invited Editorial on "Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise" J Appl Physiol, June 1, 1998; 84(6): 1825 - 1826. [Full Text] [PDF]
|
|
|
|
|
|
D. H. Silber, G. Sutliff, Q. X. Yang, M. B. Smith, L. I. Sinoway, and U. A. Leuenberger Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure J Appl Physiol, May 1, 1998; 84(5): 1551 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
