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J Appl Physiol 64: 2236-2239, 1988;
8750-7587/88 $5.00
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Journal of Applied Physiology, Vol 64, Issue 5 2236-2239, Copyright © 1988 by American Physiological Society

ARTICLES

Coronary artery embolization in closed-chest canines using flexible radiopaque plugs

M. D. Herr, J. J. McInerney, G. L. Copenhaver and D. L. Morris
Department of Medicine, Milton S. Hershey Medical Center of Pennsylvania State University 17033.

A new technique induces localized myocardial infarction in closed-chest dogs by placing discrete plugs in coronary arteries without using cumbersome coaxial catheters or guide wires. Flexible plugs, essential to this method, are formed by extruding a dental impression polymer, rendered radiopaque with sodium iodide, into spaghetti-like strands. Segments of these strands can be injected through a catheter into a selected coronary artery. Contact with blood or saline causes plugs to swell. The mean increase in plug diameter due to swelling was 27 +/- 20%. Eight anesthetized dogs were embolized via carotid approach [6 left anterior descending (LAD), 1 left circumflex (LCX), and 1 LAD and LCX]. Plug positions were monitored fluoroscopically. One animal died at 2 days postembolization. The remaining seven dogs were killed after 14-37 days. Autopsies showed complete vessel occlusion and localized infarction. Infarcts resulting from coronary artery occlusion with one, two, or three plugs involved 2-26% of the left ventricular mass.




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