Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 64: 1153-1159, 1988;
8750-7587/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Musch, T. I.
Right arrow Articles by Bradford, G. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Musch, T. I.
Right arrow Articles by Bradford, G. E.

Journal of Applied Physiology, Vol 64, Issue 3 1153-1159, Copyright © 1988 by American Physiological Society

ARTICLES

Glycogen concentrations and endurance capacity of rats with chronic heart failure

T. I. Musch, R. L. Moore, M. Riedy, P. Burke, R. Zelis, M. E. Leo, A. Bruno and G. E. Bradford
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

The endurance capacities of rats with myocardial infarctions (MI) and of rats having undergone sham operations (SHAM) were tested during a submaximal exercise regimen that consisted of swimming to exhaustion. During this test, a decrement in the endurance capacity of the MI rat was demonstrated as the SHAM rat swam 25% longer than the MI rat (65 +/- 4 vs. 52 +/- 4 min). Glycogen concentrations were measured in the liver and the white gastrocnemius, plantaris, and soleus muscles of SHAM and MI rats that were randomly divided into four subgroups, which consisted of resting control, swim to exhaustion, swim to exhaustion + 24 h recovery, and swim to exhaustion + 24 h recovery + a second swim to exhaustion. The results demonstrated that the glycogen concentrations found in the liver, white gastrocnemius, plantaris, and soleus muscles of the SHAM and MI rats belonging to the resting control groups were similar. After swimming to exhaustion the glycogen concentrations in these tissues were significantly reduced compared with those found in the resting control groups of rats, and after 24 h of recovery the glycogen concentrations in these tissues were again similar to those found in the resting control groups of rats. Since the magnitude of the glycogen depletion in the liver and the white gastrocnemius, plantaris, and soleus muscles was similar in the SHAM and MI rats and because the SHAM rats consistently swam for longer periods of time in each of the experimental groups, it would be logical to assume that the rates of glycogen utilization for the various tissues may have been greater in the MI rat during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. I. Musch, S. Wolfram, K. S. Hageman, and J. G. Pickar
Skeletal muscle ouabain binding sites are reduced in rats with chronic heart failure
J Appl Physiol, June 1, 2002; 92(6): 2326 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. Mancini, A. Benaminovitz, M. E. Cordisco, W. Karmally, and A. Weinberg
Slowed glycogen utilization enhances exercise endurance in patients with heart failure
J. Am. Coll. Cardiol., November 15, 1999; 34(6): 1807 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Pickar, J. P. Mattson, S. Lloyd, and T. I. Musch
Decreased [3H]ouabain binding sites in skeletal muscle of rats with chronic heart failure
J Appl Physiol, July 1, 1997; 83(1): 323 - 323.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online