| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 64, Issue 2 666-671, Copyright © 1988 by American Physiological Society
ARTICLES |
E. B. Olson Jr, E. H. Vidruk and J. A. Dempsey
John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, School of Medicine, University of Wisconsin, Madison 53705.
We determined the effects of carotid body excision (CBX) on eupneic ventilation and the ventilatory responses to acute hypoxia, hyperoxia, and chronic hypoxia in unanesthetized rats. Arterial PCO2 (PaCO2) and calculated minute alveolar ventilation to minute metabolic CO2 production (VA/VCO2) ratio were used to determine the ventilatory responses. The effects of CBX and sham operation were compared with intact controls (PaCO2 = 40.0 +/- 0.1 Torr, mean +/- 95% confidence limits, and VA/VCO2 = 21.6 +/- 0.1). CBX rats showed 1) chronic hypoventilation with respiratory acidosis, which was maintained for at least 75 days after surgery (PaCO2 = 48.4 +/- 1.1 Torr and VA/VCO2 = 17.9 +/- 0.4), 2) hyperventilation in response to acute hyperoxia vs. hypoventilation in intact rats, 3) an attenuated increase in VA/VCO2 in acute hypoxemia (arterial PO2 approximately equal to 49 Torr), which was 31% of the 8.7 +/- 0.3 increase in VA/VCO2 observed in control rats, 4) no ventilatory acclimatization between 1 and 24 h hypoxia, whereas intact rats had a further 7.5 +/- 1.5 increase in VA/VCO2, 5) a decreased PaCO2 upon acute restoration of normoxia after 24 h hypoxia in contrast to an increased PaCO2 in controls. We conclude that in rats carotid body chemoreceptors are essential to maintain normal eupneic ventilation and to the process of ventilatory acclimatization to chronic hypoxia.
This article has been cited by other articles:
|
|
 |
|
  M. K. Stickland, B. J. Morgan, and J. A. Dempsey Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans J. Physiol., March 15, 2008; 586(6): 1743 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Izumizaki, M. Pokorski, and I. Homma Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse J Appl Physiol, October 1, 2004; 97(4): 1401 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Bavis and G. S. Mitchell Plasticity in Respiratory Motor Control: Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats J Appl Physiol, January 1, 2003; 94(1): 399 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Rodman, A. K. Curran, K. S. Henderson, J. A. Dempsey, and C. A. Smith Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia J Appl Physiol, July 1, 2001; 91(1): 328 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. POOLE, C. A. KINDIG, and B. J. BEHNKE Effects of Emphysema on Diaphragm Microvascular Oxygen Pressure Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1081 - 1086. [Abstract] [Full Text]
|
|
|
|
 |
|
 O. A. Alea, M. A. Czapla, J. A. Lasky, N. Simakajornboon, E. Gozal, and D. Gozal PDGF-beta receptor expression and ventilatory acclimatization to hypoxia in the rat Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1625 - R1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Curran, J. R. Rodman, P. R. Eastwood, K. S. Henderson, J. A. Dempsey, and C. A. Smith Ventilatory responses to specific CNS hypoxia in sleeping dogs J Appl Physiol, May 1, 2000; 88(5): 1840 - 1852. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
