Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 63: 1902-1911, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Power, J. H.
Right arrow Articles by Nicholas, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Power, J. H.
Right arrow Articles by Nicholas, T. E.

Journal of Applied Physiology, Vol 63, Issue 5 1902-1911, Copyright © 1987 by American Physiological Society

ARTICLES

Changes in surfactant pools after a physiological increase in alveolar surfactant

J. H. Power, H. A. Barr, M. E. Jones and T. E. Nicholas
Department of Physiology, School of Medicine, Flinders University of South Australia, Adelaide.

We have used previously characterized models to investigate the reuptake of surfactant from the alveolus. In model 1, rats were swum in a water bath at 33 degrees C for 30 min, which increased tidal volume (VT) approximately 300% and frequency 60%; they were then allowed to rest for up to 4 h. In model 2, rats were exposed to 5% CO2-13% O2-82% N2 for 24 h, which increased both VT and frequency approximately 200%; these rats were then rested for up to 24 h. In both models we harvested a tissue fraction (lamellar bodies, lb) and two alveolar fractions--tubular myelin rich (alv-1) and tubular myelin poor (alv-2). Immediately after swimming, lb-dipalmitoylphosphatidylcholine (DPPClb) was 18% below the control of 0.94 +/- 0.037 (SE) mg/g wet lung (n = 24 rats; P less than 0.05); this returned to control by 2 h. Whereas DPPCalv-1 was constant at all time points, DPPCalv-2 was increased 50% above the control of 2.68 +/- 0.085 mg/g dry lung (n = 27 rats; P less than 0.001) immediately and up to 1 h after swimming. It returned to control levels between 2 and 3 h. After gas exposure, DPPC in lb, alv-1, and alv-2 was 33, 64, and 89%, respectively, above controls. All three fractions had normalized after 24 h. Our results demonstrate marked differences in the response of the surfactant system to acute and more prolonged stimuli. Of particular interest was the constancy of alv-1 with swimming, suggesting that it may be the controlled variable. However, the system appeared to be reset by prolonged hyperpnea, a process that may involve an increase in synthesis of surfactant.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Jain, C. Dodia, S. R. Bates, S. Hawgood, F. R. Poulain, and A. B. Fisher
SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L759 - L765.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. V. Lopatko, S. Orgeig, D. Palmer, S. Schurch, and C. B. Daniels
Alterations in pulmonary surfactant after rapid arousal from torpor in the marsupial Sminthopsis crassicaudata
J Appl Physiol, June 1, 1999; 86(6): 1959 - 1970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. FEHRENBACH, F. BRASCH, S. UHLIG, M. WEISSER, C. STAMME, A. WENDEL, and J. RICHTER
Early Alterations in Intracellular and Alveolar Surfactant of the Rat Lung in Response to Endotoxin
Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1630 - 1639.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online