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Journal of Applied Physiology, Vol 63, Issue 5 1739-1743, Copyright © 1987 by American Physiological Society
ARTICLES |
D. Desplanches, M. H. Mayet, B. Sempore, J. Frutoso and R. Flandrois
Unite Associee 0621, Centre National de la Recherche Scientifique, Laboratoire de Physiologie, Faculte de Medecine Grange-Blanche, Universite Claude Bernard (Lyon I), France.
The purpose of this study was to compare the effects of spontaneous recovery or recovery by treadmill training (180 min/day, 5 days/wk, 30 m/min for 8 wk) on maximal O2 uptake (VO2max), histochemical and biochemical muscular properties (soleus), of rats subsequent to 5 wk of hindlimb suspension. Spontaneous recovery reversed the 15% reduction in VO2max, whereas training posthypokinesia induced a 20% increase over control values. In the spontaneous recovery group, both citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities, decreased by hypokinesia (-40%), increased but remained 20% below the control level. In the training posthypokinesia group, an increase of these activities over control occurred (+50 and +20%, respectively). Recovery or training led to a 100% type I distribution in soleus muscle and to a recovery of all fibers' cross-sectional areas. In the spontaneous recovery group, capillaries per fiber, decreased by 46%, returned to the normal range. In the training posthypokinesia group, training induced an increase in capillaries per fiber above their control values (+23%). These results point to the plasticity of the muscle and indicate the necessity of a posthypokinesia training program for recovery of the total oxidative enzyme capacity.
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