Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 63: 1504-1510, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Czerwinski, S. M.
Right arrow Articles by Hickson, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Czerwinski, S. M.
Right arrow Articles by Hickson, R. C.

Journal of Applied Physiology, Vol 63, Issue 4 1504-1510, Copyright © 1987 by American Physiological Society

ARTICLES

Initiating regular exercise protects against muscle atrophy from glucocorticoids

S. M. Czerwinski, T. G. Kurowski, T. M. O'Neill and R. C. Hickson
Department of Physical Education, University of Illinois, Chicago 60680.

This study was undertaken to examine whether exercise can prevent glucocorticoid-induced muscle atrophy in previously untrained individuals and to evaluate whether the time of hormone administration is a determinant in the muscle's response to glucocorticoids. Female rats were divided into five groups: 1) a sedentary group that received cortisol acetate (CA, 100 mg/kg body wt); 2) a sedentary group that received the dosing vehicle (1% aqueous carboxymethyl cellulose); 3) an exercise group that received CA immediately after each exercise session; 4) an exercise group that received CA 90 min after each exercise session; and 5) an exercise group that received the vehicle. Steroid treatment and exercise (28.7 m/min for 90 min/day) were performed for 11 consecutive days. Initiation of training prevented muscle mass loss by 60% in plantaris (P) muscles and by 25% in gastrocnemius (G) muscles. Time of steroid injection was not related to the muscle sparing response. In the glucocorticoid-treated exercised rats, the activities of citrate synthase, a training marker, increased 60% in P and 37% in G. Thus the exercise appeared to cause a greater recruitment of P muscles. These data support the hypothesis that entering into an exercise program can be effective in retarding glucocorticoid-induced muscle atrophy. The degree of atrophy prevention, however, may be related to the extent that specific muscles are recruited during exercise.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. G. Menezes, C. Sobreira, L. Neder, A. L. Rodrigues-Junior, and J. A. Baddini Martinez
Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats
J Appl Physiol, February 1, 2007; 102(2): 698 - 703.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
M. J Mueller and K. S Maluf
Tissue Adaptation to Physical Stress: A Proposed "Physical Stress Theory" to Guide Physical Therapist Practice, Education, and Research
Physical Therapy, April 1, 2002; 82(4): 383 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
G. Yosipovitch, T. S. Hoon, and G. C. Leok
Suggested Rationale for Prevention and Treatment of Glucocorticoid-Induced Bone Loss in Dermatologic Patients
Arch Dermatol, April 1, 2001; 137(4): 477 - 481.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online