Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 63: 558-563, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Desplanches, D.
Right arrow Articles by Flandrois, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Desplanches, D.
Right arrow Articles by Flandrois, R.

Journal of Applied Physiology, Vol 63, Issue 2 558-563, Copyright © 1987 by American Physiological Society

ARTICLES

Structural and functional responses to prolonged hindlimb suspension in rat muscle

D. Desplanches, M. H. Mayet, B. Sempore and R. Flandrois
Laboratoire de Physiologie, Faculte de Medecine Grange-Blanche, Universite Claude Bernard, Lyon I, France.

The purpose of this study was to investigate alterations in structural and functional properties in the soleus (SOL) and extensor digitorum longus (EDL) muscles of rats after 1, 2, and 5 wk of tail suspension. Maximal O2 uptake was 19% lower after 5 wk suspension. Loss of muscle mass was greater in SOL (63%) than in EDL (22%) muscle. A reduction of type I distribution was accompanied by an increase of intermediate fiber subgroups (int I in SOL, int II in EDL). The cross-sectional area of all three fiber types was reduced by hypokinesia. The decrease in capillaries per fiber in SOL was greater than the decrease in citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities after 5 wk. No alteration in lactate dehydrogenase activity was noted. In EDL, no changes in fiber area, capillarization, and enzymatic activities occurred. Energy charge remained unchanged (0.91) whatever the muscle. These results suggest that type I fibers showed an earlier and greater susceptibility than type II fibers to suspension which is also accompanied by a decreased aerobic capacity.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Suetta, L. G. Hvid, L. Justesen, U. Christensen, K. Neergaard, L. Simonsen, N. Ortenblad, S. P. Magnusson, M. Kjaer, and P. Aagaard
Effects of aging on human skeletal muscle after immobilization and retraining
J Appl Physiol, October 1, 2009; 107(4): 1172 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Vermaelen, P. Sirvent, F. Raynaud, C. Astier, J. Mercier, A. Lacampagne, and O. Cazorla
Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy
Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1723 - C1731.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Schwarzkopf, D. Coletti, D. Sassoon, and G. Marazzi
Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway
Genes & Dev., December 15, 2006; 20(24): 3440 - 3452.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. A. Gashev, M. D. Delp, and D. C. Zawieja
Inhibition of active lymph pump by simulated microgravity in rats
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2295 - H2308.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Martin, R. de Vittoris, V. David, R. Moraes, M. Begeot, M.-H. Lafage-Proust, C. Alexandre, L. Vico, and T. Thomas
Leptin Modulates both Resorption and Formation while Preventing Disuse-Induced Bone Loss in Tail-Suspended Female Rats
Endocrinology, August 1, 2005; 146(8): 3652 - 3659.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fluck, S. Schmutz, M. Wittwer, H. Hoppeler, and D. Desplanches
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R4 - R14.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Dapp, S. Schmutz, H. Hoppeler, and M. Fluck
Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle
Physiol Genomics, December 15, 2004; 20(1): 97 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Powers and D. Bernstein
The mouse as a model of cardiovascular adaptations to microgravity
J Appl Physiol, November 1, 2004; 97(5): 1686 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
R. T. Hepple, K. D. Ross, and A. B. Rempfer
Fiber Atrophy and Hypertrophy in Skeletal Muscles of Late Middle-Aged Fischer 344 x Brown Norway F1-Hybrid Rats
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2004; 59(2): B108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. J Stevenson, P. G Giresi, A. Koncarevic, and S. C Kandarian
Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
J. Physiol., August 15, 2003; 551(1): 33 - 48.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. H. Casse, D. Desplanches, M. H. Mayet-Sornay, M. Raccurt, S. Jegou, and G. Morel
Growth Hormone Receptor Expression in Atrophying Muscle Fibers of Rats
Endocrinology, August 1, 2003; 144(8): 3692 - 3697.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Schrage, C. R. Woodman, and M. H. Laughlin
Mechanisms of flow and ACh-induced dilation in rat soleus arterioles are altered by hindlimb unweighting
J Appl Physiol, March 1, 2002; 92(3): 901 - 911.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Heaps and D. K. Bowles
Nonuniform changes in arteriolar myogenic tone within skeletal muscle following hindlimb unweighting
J Appl Physiol, March 1, 2002; 92(3): 1145 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. R. Woodman, W. G. Schrage, J. W. E. Rush, C. A. Ray, E. M. Price, E. M. Hasser, and M. H. Laughlin
Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius
J Appl Physiol, September 1, 2001; 91(3): 1091 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Sangha, S. Han, and R. E. Purdy
Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin
J Appl Physiol, August 1, 2001; 91(2): 789 - 796.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Pette
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Historical Perspectives: Plasticity of mammalian skeletal muscle
J Appl Physiol, March 1, 2001; 90(3): 1119 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Chopard, F. Pons, and J.-F. Marini
Cytoskeletal protein contents before and after hindlimb suspension in a fast and slow rat skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R323 - R330.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Schrage, C. R. Woodman, and M. H. Laughlin
Hindlimb unweighting alters endothelium-dependent vasodilation and ecNOS expression in soleus arterioles
J Appl Physiol, October 1, 2000; 89(4): 1483 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
M. A Shaffer, E. Okereke, J. L Esterhai Jr, M. A Elliott, G. A Walter, S. H Yim, and K. Vandenborne
Effects of Immobilization on Plantar-Flexion Torque, Fatigue Resistance, and Functional Ability Following an Ankle Fracture
Physical Therapy, August 1, 2000; 80(8): 769 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. K. Wilkerson, J. Muller-Delp, P. N. Colleran, and M. D. Delp
Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology
J Appl Physiol, December 1, 1999; 87(6): 2115 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Jasperse, C. R. Woodman, E. M. Price, E. M. Hasser, and M. H. Laughlin
Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries
J Appl Physiol, October 1, 1999; 87(4): 1476 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Tyml, O. Mathieu-Costello, L. Cheng, and E. G. Noble
Differential microvascular response to disuse in rat hindlimb skeletal muscles
J Appl Physiol, October 1, 1999; 87(4): 1496 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J Anderson, M. Almeida-Silveira, and C Perot
Reflex and muscular adaptations in rat soleus muscle after hindlimb suspension
J. Exp. Biol., January 10, 1999; 202(19): 2701 - 2707.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. S. Criswell, F. W. Booth, F. DeMayo, R. J. Schwartz, S. E. Gordon, and M. L. Fiorotto
Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy
Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E373 - E379.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
O. Barou, S. Palle, L. Vico, C. Alexandre, and M.-H. Lafage-Proust
Hindlimb unloading in rat decreases preosteoblast proliferation assessed in vivo with BrdU incorporation
Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E108 - E114.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Zacharová, H. Knotkova-Urbancova, and P. Hnik
Nociceptive atrophy of the rat soleus muscle induced by bone fracture: a morphometric study
J Appl Physiol, February 1, 1997; 82(2): 552 - 557.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online