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J Appl Physiol 63: 546-553, 1987;
8750-7587/87 $5.00
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Journal of Applied Physiology, Vol 63, Issue 2 546-553, Copyright © 1987 by American Physiological Society

ARTICLES

Influence of halothane on control of breathing in intact and decerebrated cats

H. Gautier, M. Bonora and D. Zaoui
Laboratoire de Physiologie Respiratoire, Faculte de Medecine Saint Antoine, Paris, France.

The effects of halothane anesthesia have been investigated in intact and in decerebrated cats. Pulmonary ventilation and breathing pattern were studied during room-air breathing, hypercapnia, and O2 inhalation. The following results have been demonstrated. First, halothane anesthesia does not modify pulmonary ventilation, but a tachypnea much more intense in intact than in decerebrated cats is observed. This indicates that halothane-induced tachypnea originates mainly in structures rostral to the brain stem. Second, decerebrated animals exhibit a breathing pattern and a ventilatory response to CO2 similar to those of intact conscious cats, suggesting that forebrain facilitatory and inhibitory influences on brain stem are cancelled out by decerebration. However, the tidal volume vs. inspiratory duration relationship observed in decerebrated cats differs from that in conscious cats. Finally, during halothane anesthesia, ventilatory response to CO2 is markedly depressed. Third, during O2 inhalation, except in decerebrated, anesthetized animals, ventilation is only slightly depressed. This suggests that central stimulatory effect of O2 is enhanced and/or that peripheral chemoreceptor drive is reduced.


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