| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 63, Issue 2 540-545, Copyright © 1987 by American Physiological Society
ARTICLES |
G. Nicolaysen, J. Shepard, M. Onizuka, T. Tanita, R. S. Hattner and N. C. Staub
Department of Physiology, University of California, San Francisco 94143.
The existence of a major gravity-independent gradient of blood flow in lungs has recently been described based on single photon emission computed tomography after intravenous injection of radioactively labeled macroaggregates. We wanted to test this hypothesis of a major gravity-independent gradient in lung blood flow in experiments with direct measurement of macroaggregate distribution in the dog lung. In six anesthetized (4 prone spontaneously breathing, 2 mechanically ventilated) dogs we injected 111In-labeled albumin macroaggregates intravenously. We killed the dogs, removed, inflated, and froze the lower lobes. We sliced the lobes 1 cm thick and made gamma camera images of the slices. We then cut three or four slices in each lobe into two or three concentric layers and measured the radioactivity per gram of tissue in a well-type gamma counter. In three of the dogs we also labeled the red cells (99mTc) so that blood volume in each sample could be determined. The gamma camera images were acquired on a 64 X 64 matrix with 4 X 4 mm pixels. On the numeric printouts from the individual slices we made two or three concentric layers and calculated activity per pixel in each layer. Neither by the well counting nor by the pixel analysis of the gamma scans did we detect any gravity-independent distribution of blood flow. With the well counting the distribution was the same whether macroaggregate activity was expressed per gram of tissue or per gram of blood-free tissue. We conclude that by direct measurements no major gravity-independent gradient of pulmonary blood flow can be detected in dog lungs.
This article has been cited by other articles:
|
|
 |
|
  H. T. Robertson and M. P. Hlastala Microsphere maps of regional blood flow and regional ventilation J Appl Physiol, March 1, 2007; 102(3): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Walther, M. J. Johansson, T. Flatebo, A. Nicolaysen, and G. Nicolaysen Marked differences between prone and supine sheep in effect of PEEP on perfusion distribution in zone II lung J Appl Physiol, September 1, 2005; 99(3): 909 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, S. McKinney, M. Krueger, and R. W. Glenny Effect of posture on regional gas exchange in pigs J Appl Physiol, December 1, 2004; 97(6): 2104 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, H. T. Robertson, and M. P. Hlastala Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia J Appl Physiol, December 1, 2000; 89(6): 2263 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, W. J. E. Lamm, S. L. Bernard, D. An, M. Chornuk, S. L. Pool, W. W. Wagner Jr, M. P. Hlastala, and H. T. Robertson Physiology of a Microgravity Environment: Selected Contribution: Redistribution of pulmonary perfusion during weightlessness and increased gravity J Appl Physiol, September 1, 2000; 89(3): 1239 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, S. McKinney, and R. W. Glenny Fractal nature of regional ventilation distribution J Appl Physiol, May 1, 2000; 88(5): 1551 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. E. Lamm and R. K. Albert Effect of zonal conditions and posture on pulmonary blood flow distribution to subpleural and interior lung J Appl Physiol, January 1, 2000; 88(1): 120 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. Bernard, H. T. Robertson, and M. P. Hlastala Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates J Appl Physiol, February 1, 1999; 86(2): 623 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, H. T. Robertson, and R. W. Glenny Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres J Appl Physiol, December 1, 1998; 85(6): 2344 - 2351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Hlastala, M. A. Chornuk, D. A. Self, H. J. Kallas, J. W. Burns, S. Bernard, N. L. Polissar, and R. W. Glenny Pulmonary blood flow redistribution by increased gravitational force J Appl Physiol, April 1, 1998; 84(4): 1278 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. McKinney, and H. T. Robertson Spatial pattern of pulmonary blood flow distribution is stable over days J Appl Physiol, March 1, 1997; 82(3): 902 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Walther, K. B. Domino, R. W. Glenny, N. L. Polissar, and M. P. Hlastala Pulmonary blood flow distribution has a hilar-to-peripheral gradient in awake, prone sheep J Appl Physiol, February 1, 1997; 82(2): 678 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakaki, Y. Taenaka, E. Tatsumi, T. Nakatani, and H. Takano Influences of nonpulsatile pulmonary flow on pulmonary functionEvaluation in a chronic animal model J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 495 - 502. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
