Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 62: 2388-2397, 1987;
8750-7587/87 $5.00
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Journal of Applied Physiology, Vol 62, Issue 6 2388-2397, Copyright © 1987 by American Physiological Society

ARTICLES

Bacterial pneumonia stimulates macromolecule secretion and ion and water fluxes in sheep trachea

R. J. Phipps, P. J. Torrealba, I. T. Lauredo, S. M. Denas, M. W. Sielczak, A. Ahmed, W. M. Abraham and A. Wanner

In vivo instillation of Pasteurella haemolytica (greater than or equal to 10(7) colony-forming units/kg) into a lobar bronchus of sheep produced bacterial pneumonia by 7 days postinoculation. Infection was verified bacteriologically and histologically. Macromolecule secretion and ion and water fluxes were subsequently measured in tracheal tissues in vitro and were compared with values from sham-infected sheep. Macromolecules were radiolabeled with 35SO4 and [3H]threonine, and we measured the secretion of macromolecule-bound radiolabel onto the mucosa. Unidirectional fluxes of Cl-, Na+, and water were measured with radioactive tracers under open-circuit and short-circuit conditions. Lung infection increased basal secretion of bound 35SO4 (by 189%) and bound [3H]-threonine (by 110%). It significantly increased net Na+ absorption under open- and short-circuit conditions and induced open-circuit net absorption of Cl- and water (16 +/- 29 microliters X cm-2 X h-1). These changes were associated with specific recruitment of neutrophils and elevated levels of arachidonate metabolites (thromboxane B2 and leukotriene B4) in the airways. Thus the bacterial pneumonia-induced changes in tracheal mucus secretion may be the result of airway inflammation.


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