Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 62: 2338-2347, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hauschka, E. O.
Right arrow Articles by Edgerton, V. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hauschka, E. O.
Right arrow Articles by Edgerton, V. R.

Journal of Applied Physiology, Vol 62, Issue 6 2338-2347, Copyright © 1987 by American Physiological Society

ARTICLES

Size and metabolic properties of single muscle fibers in rat soleus after hindlimb suspension

E. O. Hauschka, R. R. Roy and V. R. Edgerton

The effects of 28 days of hindlimb suspension (HS) and HS plus 10 daily forceful lengthening contractions on rat soleus muscle fibers were studied. Compared with age-matched controls (CON), soleus wet weights of suspended rats were significantly decreased (approximately 49%). In HS rats, the light adenosinetriphosphatase (ATPase) fibers (staining lightly for myosin ATPase, pH = 8.8) atrophied more than the dark ATPase fibers (staining darkly for myosin ATPase, pH = 8.8). Single-fiber alpha-glycerophosphate dehydrogenase (GPD) and succinate dehydrogenase (SDH) activities and the proportion of dark ATPase fibers were higher in HS than CON rats. Daily forceful lengthening contractions did not prevent the suspension-induced changes. These results considered in conjunction with a collaborative study on the mechanical properties of HS rats (Roy et al., accompanying paper) suggest a shift in the contractile potential of the muscle following HS without a deficit in SDH, a metabolic property commonly associated with resistance to fatigue. The results support the view that soleus muscle fibers can change from a slow-twitch oxidative to a fast-twitch oxidative-glycolytic profile, but rarely to a fast-twitch glycolytic one, and that SDH and GPD activity per volume of tissue can be maintained or increased even when there are severe losses of contractile proteins.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. Martinez, A. C. Vailas, R. Vanderby Jr., and R. E. Grindeland
Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1552 - R1560.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. McClung, R. W. Thompson, L. L. Lowe, and J. A. Carson
RhoA expression during recovery from skeletal muscle disuse
J Appl Physiol, April 1, 2004; 96(4): 1341 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. V. Thompson and J. A. Shoeman
Contractile function of single muscle fibers after hindlimb unweighting in aged rats
J Appl Physiol, January 1, 1998; 84(1): 229 - 235.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online