Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 62: 2264-2272, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taveira da Silva, A. M.
Right arrow Articles by Gillis, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taveira da Silva, A. M.
Right arrow Articles by Gillis, R. A.

Journal of Applied Physiology, Vol 62, Issue 6 2264-2272, Copyright © 1987 by American Physiological Society

ARTICLES

Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat

A. M. Taveira da Silva, B. Hartley, P. Hamosh, J. A. Quest and R. A. Gillis

The aim of this study was to evaluate the cardiorespiratory effects of intravenously administered gamma-aminobutyric acid (GABA) alpha-(4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, THIP) and beta-(baclofen) receptor agonists and to locate the site of action of these drugs in the brain. THIP and baclofen were administered to alpha-chloralose-anesthetized cats while minute ventilation (VE), arterial blood pressure (AP), and heart rate were monitored. THIP, in doses of 0.5 to 2 mg/kg decreased VE, tidal volume (VT), and AP. No changes in respiratory rate (f) or inspiratory (TI) or expiratory (TE) duration were observed. Baclofen, in doses of 0.5 to 4 mg/kg, decreased VE, f, and AP. VT and TI increased and an "apneustic" breathing pattern was seen. THIP (9.5 micrograms), applied bilaterally to the glycine-sensitive area of the ventral medulla, reproduced the effects seen with intravenous administration. Application of 10 micrograms of bicuculline bilaterally to this area reversed the effects of intravenous THIP but not those of baclofen. Baclofen (5.6-56 micrograms), administered by the intracisternal route, produced the same respiratory effects seen with intravenous administration. We conclude that activation of GABA alpha- and beta-receptors produces cardiorespiratory depression. However, this is accomplished by different mechanisms and by actions exerted at different central nervous system sites.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
Q. Liu, T. F. Lowry, and M. T. T. Wong-Riley
Postnatal changes in ventilation during normoxia and acute hypoxia in the rat: implication for a sensitive period
J. Physiol., December 15, 2006; 577(3): 957 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Wasserman, M. Ferreira Jr., N. Sahibzada, Y. M. Hernandez, and R. A. Gillis
GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1423 - R1441.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Tabata, H. Kurosawa, Y. Kikuchi, W. Hida, H. Ogawa, S. Okabe, Y. Tun, T. Hattori, and K. Shirato
Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1411 - R1419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. C. Chitravanshi and H. N. Sapru
GABA receptors in the phrenic nucleus of the rat
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R420 - R428.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online