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J Appl Physiol 62: 1460-1464, 1987;
8750-7587/87 $5.00
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Journal of Applied Physiology, Vol 62, Issue 4 1460-1464, Copyright © 1987 by American Physiological Society

ARTICLES

Effect of high-intensity exercise on the VE-VCO2 relationship

V. J. Caiozzo, J. A. Davis, D. J. Berriman, R. B. Vandagriff and C. A. Prietto

The intrinsic relationship between ventilation (VE) and carbon dioxide output (VCO2) is described by the modified alveolar ventilation equation VE = VCO2 k/PaCO2(1-VD/VT) where PaCO2 is the partial pressure of CO2 in the arterial blood and VD/VT is the dead space fraction of the tidal volume. Previous investigators have reported that high-intensity exercise uncouples VE from VCO2; however, they did not measure the PaCO2 and VD/VT components of the overall relationship. In an attempt to provide a more complete analysis of the effects of high-intensity exercise on the VE-VCO2 relationship, we undertook an investigation where five subjects volunteered to perform three steady-state tests (SS1, SS2, SS3) at 60 W. One week after SS1 each subject was required to perform repeated 1-min bouts of exercise corresponding to a work rate of approximately 140% of maximal oxygen uptake (VO2max). Two and 24 h later the subjects performed SS2 and SS3, respectively. This exercise intervention caused PaCO2 during SS2 and SS3 to be regulated (P less than 0.01) approximately 4 Torr below the control (SS1) value of 38.8 Torr. Additionally, significant alterations were noted for VCO2 with corresponding values of 1.15 (SS1), 1.10 (SS2), and 1.04 (SS3) l/min. No changes were noted in either VD/VT or VE. In summary, it seems reasonable to suggest that the disproportionate increase in VE with respect to VCO2 noted in earlier work does not reflect an uncoupling. Rather the slope of the VE-VCO2 relationship is increased in a predictable manner as described by the modified alveolar ventilation equation.


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X.-G. Sun, J. E. Hansen, N. Garatachea, T. W. Storer, and K. Wasserman
Ventilatory Efficiency during Exercise in Healthy Subjects
Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1443 - 1448.
[Abstract] [Full Text] [PDF]


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