| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 62, Issue 3 999-1005, Copyright © 1987 by American Physiological Society
ARTICLES |
E. Jansson and L. Kaijser
Substrate utilization during exercise at 65% of maximal O2 uptake (VO2 max) and biochemical characteristics of vastus lateralis were compared between five endurance-trained (T) and five untrained subjects (U). The oxidative enzyme activities were 100% greater in T than in U, and VO2 max was 50% higher. A greater proportion of ATP regeneration occurred through oxidative processes in T than in U (smaller leg lactate release and smaller muscle lactate accumulation). The respiratory exchange ratio together with the local leg respiratory quotient indicated a greater contribution of fat to oxidative metabolism in T than U (53 vs. 33%). No difference, however, in the ratio of plasma free fatty acid extraction to O2 extraction by the working legs was found between T and U. Thus it could be calculated that a greater fraction of fat oxidation would have been covered by intramuscular triglycerides in T than in U (34 vs. 15%, P less than 0.05). T in comparison to U were further characterized by a smaller glycogen breakdown and a smaller glucose uptake, which may have been one contributing factor that prevented the blood glucose level from falling in T. The greater leg muscle citrate concentration in T could have been one factor mediating a lower carbohydrate utilization as a response to an increase in the relative proportion of fat oxidation.
This article has been cited by other articles:
|
|
 |
|
  C. Moro, S. Bajpeyi, and S. R. Smith Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E203 - E213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Hannukainen, P. Nuutila, B. Ronald, J. Kaprio, U. M. Kujala, T. Janatuinen, O. J. Heinonen, J. Kapanen, T. Viljanen, M. Haaparanta, et al. Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins J. Physiol., January 1, 2007; 578(1): 347 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Hannukainen, P. Nuutila, J. Kaprio, O. J Heinonen, U. M. Kujala, T. Janatuinen, T. Ronnemaa, J. Kapanen, M. Haaparanta-Solin, T. Viljanen, et al. Relationship between local perfusion and FFA uptake in human skeletal muscle--no effect of increased physical activity and aerobic fitness J Appl Physiol, November 1, 2006; 101(5): 1303 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Kevin. A. Jacobs, R. M. Krauss, J. A. Fattor, M. A. Horning, A. L. Friedlander, T. A. Bauer, T. A. Hagobian, E. E. Wolfel, and G. A. Brooks Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E656 - E665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kiens Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance Physiol Rev, January 1, 2006; 86(1): 205 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. LeBlanc, K. R. Howarth, M. J. Gibala, and G. J. F. Heigenhauser Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise J Appl Physiol, December 1, 2004; 97(6): 2148 - 2153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. C. van Loon Use of intramuscular triacylglycerol as a substrate source during exercise in humans J Appl Physiol, October 1, 2004; 97(4): 1170 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Knoepfli, M C Riddell, E Ganzoni, A Burki, B Villiger, and S P von Duvillard Off seasonal and pre-seasonal assessment of circulating energy sources during prolonged running at the anaerobic threshold in competitive triathletes Br. J. Sports Med., August 1, 2004; 38(4): 402 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Stannard and N. A. Johnson Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty' genes? J. Physiol., February 1, 2004; 554(3): 595 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Norrbom, C. J. Sundberg, H. Ameln, W. E. Kraus, E. Jansson, and T. Gustafsson PGC-1{alpha} mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle J Appl Physiol, January 1, 2004; 96(1): 189 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Helge, A. Dobrzyn, B. Saltin, and J. Gorski Exercise and training effects on ceramide metabolism in human skeletal muscle Exp Physiol, January 1, 2004; 89(1): 119 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Watt, G. J. F. Heigenhauser, and L. L. Spriet Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J Appl Physiol, October 1, 2002; 93(4): 1185 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mittendorfer, J. F. Horowitz, and S. Klein Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E58 - E65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. C. Van Aggel-Leijssen, W. H. M. Saris, A. J. M. Wagenmakers, J. M. Senden, and M. A. Van Baak Effect of exercise training at different intensities on fat metabolism of obese men J Appl Physiol, March 1, 2002; 92(3): 1300 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Goodpaster, J. He, S. Watkins, and D. E. Kelley Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5755 - 5761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Virkamaki, E. Korsheninnikova, A. Seppala-Lindroos, S. Vehkavaara, T. Goto, J. Halavaara, A.-M. Hakkinen, and H. Yki-Jarvinen Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle Diabetes, October 1, 2001; 50(10): 2337 - 2343. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Carter, C. Rennie, and M. A. Tarnopolsky Substrate utilization during endurance exercise in men and women after endurance training Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E898 - E907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Hunter, C. J. Wetzstein, D. A. Fields, A. Brown, and M. M. Bamman Resistance training increases total energy expenditure and free-living physical activity in older adults J Appl Physiol, September 1, 2000; 89(3): 977 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F Horowitz and S. Klein Lipid metabolism during endurance exercise Am. J. Clinical Nutrition, August 1, 2000; 72(2): 558S - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Pendergast, J. J. Leddy, and J. T. Venkatraman A Perspective on Fat Intake in Athletes J. Am. Coll. Nutr., June 1, 2000; 19(3): 345 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Dyck, D. Miskovic, L. Code, J. J. F. P. Luiken, and A. Bonen Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus Am J Physiol Endocrinol Metab, May 1, 2000; 278(5): E778 - E785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Horvath, C. K. Eagen, N. M. Fisher, J. J. Leddy, and D. R. Pendergast The Effects of Varying Dietary Fat on Performance and Metabolism in Trained Male and Female Runners J. Am. Coll. Nutr., February 1, 2000; 19(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dela, K. J. Mikines, J. J. Larsen, and H. Galbo Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise J Appl Physiol, December 1, 1999; 87(6): 2059 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rico-Sanz, E. L. Thomas, G. Jenkinson, S. Mierisova, R. Iles, and J. D. Bell Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS J Appl Physiol, December 1, 1999; 87(6): 2068 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, E. E. Wolfel, G. E. Butterfield, G. D. Lopaschuk, G. A. Casazza, M. A. Horning, and G. A. Brooks Active muscle and whole body lactate kinetics after endurance training in men J Appl Physiol, November 1, 1999; 87(5): 1684 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. C. van Loon, A. E. Jeukendrup, W. H. M. Saris, and A. J. M. Wagenmakers Effect of training status on fuel selection during submaximal exercise with glucose ingestion J Appl Physiol, October 1, 1999; 87(4): 1413 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Horowitz, R. J. Braudy, W. H. Martin III, and S. Klein Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine Am J Physiol Endocrinol Metab, August 1, 1999; 277(2): E325 - E331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, G. E. Butterfield, E. E. Wolfel, G. D. Lopaschuk, G. A. Casazza, M. A. Horning, and G. A. Brooks Muscle net glucose uptake and glucose kinetics after endurance training in men Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E81 - E92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, G. A. Casazza, M. A. Horning, A. Usaj, and G. A. Brooks Endurance training increases fatty acid turnover, but not fat oxidation, in young men J Appl Physiol, June 1, 1999; 86(6): 2097 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman and G. A. Brooks Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men J Appl Physiol, February 1, 1999; 86(2): 479 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, G. E. Butterfield, E. E. Wolfel, G. A. Casazza, G. D. Lopaschuk, and G. A. Brooks Evaluation of exercise and training on muscle lipid metabolism Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E106 - E117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, G. A. Casazza, M. A. Horning, T. F. Buddinger, and G. A. Brooks Effects of exercise intensity and training on lipid metabolism in young women Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E853 - E863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Dyck and A. Bonen Muscle contraction increases palmitate esterification and oxidation and triacylglycerol oxidation Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E888 - E896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Gleim and B. Glace Carnitine as an Ergogenic Aid in Health and Disease J. Am. Coll. Nutr., June 1, 1998; 17(3): 203 - 204. [Full Text] [PDF]
|
|
|
|
|
|
S. Sial, A. R. Coggan, R. C. Hickner, and S. Klein Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects Am J Physiol Endocrinol Metab, May 1, 1998; 274(5): E785 - E790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Odland, G. J. F. Heigenhauser, D. Wong, M. G. Hollidge-Horvat, and L. L. Spriet Effects of increased fat availability on fat-carbohydrate interaction during prolonged exercise in men Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R894 - R902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Sidossis, R. R. Wolfe, and A. R. Coggan Regulation of fatty acid oxidation in untrained vs. trained men during exercise Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E510 - E515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Richter, P. Jensen, B. Kiens, and S. Kristiansen Sarcolemmal glucose transport and GLUT-4 translocation during exercise are diminished by endurance training Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E89 - E95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Jeukendrup, M. Mensink, W. H. M. Saris, and A. J. M. Wagenmakers Exogenous glucose oxidation during exercise in endurance-trained and untrained subjects J Appl Physiol, March 1, 1997; 82(3): 835 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Goforth, Jr., D. A. Arnall, B. L. Bennett, and P. G. Law Persistence of supercompensated muscle glycogen in trained subjects after carbohydrate loading J Appl Physiol, January 1, 1997; 82(1): 342 - 347. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
