Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 62: 1285-1298, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Armstrong, R. B.
Right arrow Articles by Laughlin, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Armstrong, R. B.
Right arrow Articles by Laughlin, M. H.

Journal of Applied Physiology, Vol 62, Issue 3 1285-1298, Copyright © 1987 by American Physiological Society

ARTICLES

Distribution of blood flow in muscles of miniature swine during exercise

R. B. Armstrong, M. D. Delp, E. F. Goljan and M. H. Laughlin

The purpose of this study was to determine how the distribution of blood flow within and among the skeletal muscles of miniature swine (22 +/- 1 kg body wt) varies as a function of treadmill speed. Radiolabeled microspheres were used to measure cardiac output (Q) and tissue blood flows in preexercise and at 3-5 min of treadmill exercise at 4.8, 8.0, 11.3, 14.5, and 17.7 km/h. All pigs (n = 8) attained maximal O2 consumption (VO2max) (60 +/- 4 ml X min-1 X kg-1) by the time they ran at 17.7 km/h. At VO2max, 87% of Q (9.9 +/- 0.5 l/min) was to skeletal muscle, which constituted 36 +/- 1% of body mass. Average total muscle blood flow at VO2max was 127 +/- 14 ml X min-1 X 100 g-1; average limb muscle flow was 135 +/- 17 ml X min-1 X 100 g-1. Within the limb muscles, blood flow was distributed so that the deep red parts of extensor muscles had flows about two times higher than the more superficial white portions of the same muscles; the highest muscle blood flows occurred in the elbow flexors (brachialis: 290 +/- 44 ml X min-1 X 100 g-1). Peak exercise blood flows in the limb muscles were proportional (P less than 0.05) to the succinate dehydrogenase activities (r = 0.84), capillary densities (r = 0.78), and populations of oxidative (slow-twitch oxidative + fast-twitch oxidative-glycolytic) fiber types (r = 0.93) in the muscles. Total muscle blood flow plotted as a function of exercise intensity did not peak until the pigs attained VO2max, although flows in some individual muscles showed a plateau in this relationship at submaximal exercise intensities. The data demonstrate that blood flow in skeletal muscles of miniature swine is distributed heterogeneously and varies in relation to fiber type composition and exercise intensity.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
D. J. Duncker and R. J. Bache
Regulation of Coronary Blood Flow During Exercise
Physiol Rev, July 1, 2008; 88(3): 1009 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
E. A. Jones, A. S. Jong, and D. J. Ellerby
The effects of acute temperature change on swimming performance in bluegill sunfish Lepomis macrochirus
J. Exp. Biol., May 1, 2008; 211(9): 1386 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. N. Colleran, B. J. Behnke, M. K. Wilkerson, A. J. Donato, and M. D. Delp
Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca2+ release mechanism
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1577 - R1585.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. McAllister, S. C. Newcomer, E. R. Pope, J. R. Turk, and M. H. Laughlin
Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine
J Appl Physiol, January 1, 2008; 104(1): 186 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. T. Kuipers, C. L. Sauder, M. L. Kearney, and C. A. Ray
Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3432 - H3439.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Saltin
Exercise hyperaemia: magnitude and aspects on regulation in humans
J. Physiol., September 15, 2007; 583(3): 819 - 823.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Merkus, B. Houweling, V. J. de Beer, Z. Everon, and D. J. Duncker
Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction
J. Physiol., May 1, 2007; 580(3): 907 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. DeLorey, J. J. Hamann, Z. Valic, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter
{alpha}-Adrenergic receptor responsiveness is preserved during prolonged exercise
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H392 - H398.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. J. Behnke, R. D. Prisby, L. A. Lesniewski, A. J. Donato, H. M. Olin, and M. D. Delp
Influence of ageing and physical activity on vascular morphology in rat skeletal muscle
J. Physiol., September 1, 2006; 575(2): 617 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. L. Marsh and D. J. Ellerby
Partitioning locomotor energy use among and within muscles Muscle blood flow as a measure of muscle oxygen consumption
J. Exp. Biol., July 1, 2006; 209(13): 2385 - 2394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. Donato, A. Uberoi, D. W. Wray, S. Nishiyama, L. Lawrenson, and R. S. Richardson
Differential effects of aging on limb blood flow in humans
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H272 - H278.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. P Mortensen, E. A Dawson, C. C Yoshiga, M. K Dalsgaard, R. Damsgaard, N. H Secher, and J. Gonzalez-Alonso
Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans
J. Physiol., July 1, 2005; 566(1): 273 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Gruionu, J. B. Hoying, L. G. Gruionu, M. H. Laughlin, and T. W. Secomb
Structural adaptation increases predicted perfusion capacity after vessel obstruction in arteriolar arcade network of pig skeletal muscle
Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2778 - H2784.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. J Ellerby, H. T Henry, J. A Carr, C. I Buchanan, and R. L Marsh
Blood flow in guinea fowl Numida meleagris as an indicator of energy expenditure by individual muscles during walking and running
J. Physiol., April 15, 2005; 564(2): 631 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. D. Shipley, S. J. Kim, and J. M. Muller-Delp
Time course of flow-induced vasodilation in skeletal muscle: contributions of dilator and constrictor mechanisms
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1499 - H1507.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. W. Mitchell, N. Turner, A. J. Hulbert, P. L. Else, J. A. Hawley, J. S. Lee, C. R. Bruce, and S. J. Blanksby
Exercise alters the profile of phospholipid molecular species in rat skeletal muscle
J Appl Physiol, November 1, 2004; 97(5): 1823 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Delp and D. S. O'Leary
Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise
J Appl Physiol, September 1, 2004; 97(3): 1112 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Hogan, B. Grassi, M. Samaja, C. M. Stary, and L. B. Gladden
Effect of contraction frequency on the contractile and noncontractile phases of muscle venous blood flow
J Appl Physiol, September 1, 2003; 95(3): 1139 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. M. Kowalchuk, and D. H. Paterson
Relationship between pulmonary O2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise
J Appl Physiol, July 1, 2003; 95(1): 113 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. E. Rush, J. R. Turk, and M. H. Laughlin
Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1378 - H1387.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Dobson and L. B. Gladden
Effect of rhythmic tetanic skeletal muscle contractions on peak muscle perfusion
J Appl Physiol, January 1, 2003; 94(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Miyauchi, S. Maeda, M. Iemitsu, T. Kobayashi, Y. Kumagai, I. Yamaguchi, and M. Matsuda
Exercise causes a tissue-specific change of NO production in the kidney and lung
J Appl Physiol, January 1, 2003; 94(1): 60 - 68.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. P. Mattson, T. A. Miller, D. C. Poole, and M. D. Delp
Fiber Composition and Oxidative Capacity of Hamster Skeletal Muscle
J. Histochem. Cytochem., December 1, 2002; 50(12): 1685 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Fahlman, W. C. Lin, W. B. Whitman, and S. R. Kayar
Modulation of decompression sickness risk in pigs with caffeine during H2 biochemical decompression
J Appl Physiol, November 1, 2002; 93(5): 1583 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Muller-Delp, S. A. Spier, M. W. Ramsey, and M. D. Delp
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1662 - H1672.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
M. B. Gordon, R. Jain, J. A Beckman, and M. A Creager
The contribution of nitric oxide to exercise hyperemia in the human forearm
Vascular Medicine, August 1, 2002; 7(3): 163 - 168.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
D. B Haitsma, D. Bac, N. Raja, F. Boomsma, P. D Verdouw, and D. J Duncker
Minimal impairment of myocardial blood flow responses to exercise in the remodeled left ventricle early after myocardial infarction, despite significant hemodynamic and neurohumoral alterations
Cardiovasc Res, December 1, 2001; 52(3): 417 - 428.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. J Jones, N. J Dietz, C. L Heaps, J. L Parker, and M. Sturek
Calcium buffering in coronary smooth muscle after chronic occlusion and exercise training
Cardiovasc Res, August 1, 2001; 51(2): 359 - 367.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson, J. W. E. Rush, J. R. Turk, E. M. Price, and M. H. Laughlin
Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries
J Appl Physiol, March 1, 2001; 90(3): 1102 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
R. W. GRANGE, E. ISOTANI, K. S. LAU, K. E. KAMM, P. L. HUANG, and J. T. STULL
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles
Physiol Genomics, February 7, 2001; 5(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. P. Foster, A. H. Feiveson, R. Glowinski, M. Izygon, and A. M. Boriek
A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2304 - R2316.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson and M. H. Laughlin
Chronic exercise training does not alter pulmonary vasorelaxation in normal pigs
J Appl Physiol, June 1, 2000; 88(6): 2008 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson, J. L. Parker, and M. H. Laughlin
Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs
J Appl Physiol, February 1, 2000; 88(2): 443 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
K. S. LAU, R. W. GRANGE, E. ISOTANI, I. H. SARELIUS, K. E. KAMM, P. L. HUANG, and J. T. STULL
nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle
Physiol Genomics, January 24, 2000; 2(1): 21 - 27.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Bellizzi, K. A. D. King, S. K. Cushman, and P. G. Weyand
Does the application of ground force set the energetic cost of cross-country skiing?
J Appl Physiol, November 1, 1998; 85(5): 1736 - 1743.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Maeda, T. Miyauchi, T. Kobayashi, K. Goto, and M. Matsuda
Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs
J Appl Physiol, August 1, 1998; 85(2): 425 - 431.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Stubenitsky, P. D Verdouw, and D. J Duncker
Autonomic control of cardiovascular performance and whole body O2 delivery and utilization in swine during treadmill exercise
Cardiovasc Res, August 1, 1998; 39(2): 459 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. K. Shoemaker, J. R. Halliwill, R. L. Hughson, and M. J. Joyner
Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery
Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2388 - H2395.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. McAllister, B. L. Reiter, J. F. Amann, and M. H. Laughlin
Skeletal muscle biochemical adaptations to exercise training in miniature swine
J Appl Physiol, June 1, 1997; 82(6): 1862 - 1868.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. McAllister and M. H. Laughlin
Short-term exercise training alters responses of porcine femoral and brachial arteries
J Appl Physiol, May 1, 1997; 82(5): 1438 - 1444.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Harms, M. A. Babcock, S. R. McClaran, D. F. Pegelow, G. A. Nickele, W. B. Nelson, and J. A. Dempsey
Respiratory muscle work compromises leg blood flow during maximal exercise
J Appl Physiol, May 1, 1997; 82(5): 1573 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Maeda, T. Miyauchi, M. Sakane, M. Saito, S. Maki, K. Goto, and M. Matsuda
Does endothelin-1 participate in the exercise-induced changes of blood flow distribution of muscles in humans?
J Appl Physiol, April 1, 1997; 82(4): 1107 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Aaker and M. H. Laughlin
Diaphragm arterioles are less responsive to alpha 1- adrenergic constriction than gastrocnemius arterioles
J Appl Physiol, May 1, 2002; 92(5): 1808 - 1816.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Muller-Delp, S. A. Spier, M. W. Ramsey, L. A. Lesniewski, A. Papadopoulos, J. D. Humphrey, and M. D. Delp
Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles
Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1843 - H1854.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online