Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 62: 223-228, 1987;
8750-7587/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Allen, J. L.
Right arrow Articles by Fredberg, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allen, J. L.
Right arrow Articles by Fredberg, J. J.

Journal of Applied Physiology, Vol 62, Issue 1 223-228, Copyright © 1987 by American Physiological Society

ARTICLES

Heterogeneity of mean alveolar pressure during high-frequency oscillations

J. L. Allen, I. D. Frantz 3rd and J. J. Fredberg

Mean alveolar pressure may exceed mean airway pressure during high-frequency oscillations (HFO). To assess the magnitude of this effect and its regional heterogeneity, we studied six excised dog lungs during HFO [frequency (f) 2-32 Hz; tidal volume (VT) 5-80 ml] at transpulmonary pressures (PL) of 6, 10, and 25 cmH2O. We measured mean pressure at the airway opening (Pao), trachea (Ptr), and four alveolar locations (PA) using alveolar capsules. Pao was measured at the oscillator pump, wherein the peak dynamic head was less than 0.2 cmH2O. Since the dynamic head was negligible here, and since these were excised lungs, Pao thus represented true applied transpulmonary pressure. Ptr increasingly underestimated Pao as f and VT increased, with Pao - Ptr approaching 8 cmH2O. PA (averaged over all locations) and Pao were nearly equal at all PL's, f's, and VT's, except at PL of 6, f 32 Hz, and VT 80 ml, where (PA - Pao) was 3 cmH2O. Remarkably, mean pressure in the base exceeded that in the apex increasingly as f and VT increased, the difference approaching 3 cmH2O at high f and VT. We conclude that, although global alveolar overdistension assessed by PA - Pao is small during HFO under these conditions, larger regional heterogeneity in PA's exists that may be a consequence of airway branching angle asymmetry and/or regional flow distribution.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. J. Pillow, H. Neil, M. H. Wilkinson, and C. A. Ramsden
Effect of I/E ratio on mean alveolar pressure during high-frequency oscillatory ventilation
J Appl Physiol, July 1, 1999; 87(1): 407 - 414.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. Thome and F. Pohlandt
Effect of the TI/TE ratio on mean intratracheal pressure in high-frequency oscillatory ventilation
J Appl Physiol, May 1, 1998; 84(5): 1520 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Bramble and F. Jenkins Jr
Mammalian locomotor-respiratory integration: implications for diaphragmatic and pulmonary design
Science, October 8, 1993; 262(5131): 235 - 240.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online