Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 61: 2186-2193, 1986;
8750-7587/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laitinen, L. A.
Right arrow Articles by Widdicombe, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laitinen, L. A.
Right arrow Articles by Widdicombe, J. G.

Journal of Applied Physiology, Vol 61, Issue 6 2186-2193, Copyright © 1986 by American Physiological Society

ARTICLES

Relationship between tracheal mucosal thickness and vascular resistance in dogs

L. A. Laitinen, N. P. Robinson, A. Laitinen and J. G. Widdicombe

We have measured changes in tracheal mucosal thickness and tracheal vascular resistance in the dog. A probe was used to detect changes in height with time of the tracheal epithelium relative to an underlying cartilage. Tracheal vascular resistance was determined by perfusing a cranial tracheal artery at constant flow and measuring inflow pressure. Various drugs injected close-arterially were tested in 20 greyhounds anesthetized with pentobarbital sodium. Bradykinin, histamine, and methacholine significantly (P less than 0.01) decreased vascular resistance (-39.3 +/- 3.7, -47.3 +/- 4.2, and -22.5 +/- 5.2%, respectively) and increased the thickness of the mucosa (119.0 +/- 25.0, 61.9 +/- 25.0, and 46.3 +/- 6.4 micron). Substance P, vasoactive intestinal peptide, prostaglandin F2 alpha, and prostaglandin E, had large vasodilator actions (-31.4 +/- 5.0, -34.3 +/- 2.2, -21.9 +/- 2.8, and -31.5 +/- 2.4%) but only small effects on mucosal thickness (12.3 +/- 3.9, 13.0 +/- 3.4, 16.7 +/- 6.5, and 8.7 +/- 2.9 micron, respectively). Phenylephrine hydrochloride increased vascular resistance (19.8 +/- 1.7%) and decreased mucosal thickness (-23.9 +/- 3.1 micron). Thus airway vascular resistance and mucosal thickness always change in opposite directions, but drugs have different relative actions on the two variables. Even with large vasodilatations, the absolute changes in mucosal thickness were small and were unlikely to have an appreciable effect on tracheal airway resistance.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Meinero, G. Coletta, L. Dutto, M. Milanese, G. Nova, A. Sciolla, R. Pellegrino, and V. Brusasco
Mechanical response to methacholine and deep inspiration in supine men
J Appl Physiol, January 1, 2007; 102(1): 269 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. N. Feltis, D. Wignarajah, L. Zheng, C. Ward, D. Reid, R. Harding, and E. H. Walters
Increased Vascular Endothelial Growth Factor and Receptors: Relationship to Angiogenesis in Asthma
Am. J. Respir. Crit. Care Med., June 1, 2006; 173(11): 1201 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. J. Janssen, H. Lu-Chao, and S. Netherton
Responsiveness of canine bronchial vasculature to excitatory stimuli and to cooling
Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L930 - L937.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online