Journal of Applied Physiology Virginia Commonwealth University
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 61: 2129-2135, 1986;
8750-7587/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brauer, R. W.
Right arrow Articles by Vorus, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brauer, R. W.
Right arrow Articles by Vorus, W. S.

Journal of Applied Physiology, Vol 61, Issue 6 2129-2135, Copyright © 1986 by American Physiological Society

ARTICLES

Effects of prolonged simultaneous exposure of CD-1 mice to high pressures and inert gas narcosis

R. W. Brauer, J. A. Dutcher and W. S. Vorus

Addition of N2 to the heliox used in pressure conditioning exposures reduces or suppresses the increase in convulsion threshold pressure (Pc) as well as the change in compression rate effect resulting from pressure exposures in the absence of N2; 18 atm N2 neutralizes the effect of 80 ATA total pressure so that Pc remains at a constant level throughout the conditioning period. Since N2 habituation is much slower than pressure conditioning (t1/2 6 days vs. 12 h), this precludes mere addition of pressure and N2 effects in this situation. In contrast to Pc, anesthesia tolerance of mice exposed to 80 ATA in the presence of 18 atm N2 increases even more (25%) than at the same PN2 but at a total pressure of only 18 ATA, indicating that pressure reversal of anesthesia does not extend to the habituation events. The implications of the striking asymmetry between the effects of protracted high pressure and inert gas narcotic exposures for an understanding of the nature of the supposed IG/HP antagonism are discussed.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. B. Dean, D. K. Mulkey, A. J. Garcia III, R. W. Putnam, and R. A. Henderson III
Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures
J Appl Physiol, September 1, 2003; 95(3): 883 - 909.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online