Journal of Applied Physiology, Vol 61, Issue 4 1352-1357, Copyright © 1986 by American Physiological Society

ARTICLES

Influence of central venous pressure change on plasma vasopressin in humans

P. Norsk, F. Bonde-Petersen and J. Warberg

After overnight food and fluid restriction, nine healthy males were examined before, during, and after lower body positive pressure (LBPP) of 11 +/- 1 mmHg (mean +/- SE) for 30 min and before, during, and after graded lower body negative pressure (LBNP) of -10 +/- 1, -20 +/- 2, and -30 +/- 2 mmHg for 20 min each. LBPP and LBNP were performed with the subject in the supine position in a plastic box encasing the subject from the xiphoid process and down, thus including the splanchnic area. Central venous pressure (CVP) during supine rest was 7.5 +/- 0.5 mmHg, increasing to 13.4 +/- 0.8 mmHg (P less than 0.001) during LBPP and decreasing significantly at each step of LBNP to 2.0 +/- 0.5 mmHg (P less than 0.001) at 15 min of -30 +/- 2 mmHg LBNP. Plasma arginine vasopressin (AVP) did not change significantly in face of this large variation in CVP of 11.4 mmHg. Mean arterial pressure increased significantly during LBPP from 100 +/- 2 to 117 +/- 3 Torr (P less than 0.001) and only at one point during LBNP of -30 +/- 2 mmHg from 102 +/- 1 to 115 +/- 5 mmHg (P less than 0.05). Heart rate did not change during LBPP but increased slightly from 51 +/- 3 to 55 +/- 3 beats/min (P less than 0.05) only at 7 min of LBNP of -30 +/- 2 mmHg. Plasma osmolality, sodium, and potassium did not change during the experiment. Hemoglobin concentration increased during LBPP and LBNP, whereas hematocrit only increased during LBNP.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				B. T. A. Esch, J. M. Scott, and D. E. R. Warburton Construction of a lower body negative pressure chamber Advan Physiol Educ, March 1, 2007; 31(1): 76 - 81. [Abstract] [Full Text] [PDF]

				W. H. Cooke, K. L. Ryan, and V. A. Convertino Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans J Appl Physiol, April 1, 2004; 96(4): 1249 - 1261. [Abstract] [Full Text] [PDF]

				B. Pump, T. Kamo, A. Gabrielsen, P. Bie, N. J. Christensen, and P. Norsk Central volume expansion is pivotal for sustained decrease in heart rate during seated to supine posture change Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1274 - H1279. [Abstract] [Full Text] [PDF]

				B. Pump, A. Gabrielsen, N. J. Christensen, P. Bie, M. Bestle, and P. Norsk Mechanisms of inhibition of vasopressin release during moderate antiorthostatic posture change in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R229 - R235. [Abstract] [Full Text] [PDF]

				B. Pump, N. J. Christensen, R. Videbak, J. Warberg, O. Hendriksen, and P. Norsk Left atrial distension and antiorthostatic decrease in arterial pressure and heart rate in humans Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2632 - H2638. [Abstract] [Full Text] [PDF]