| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 60, Issue 4 1401-1406, Copyright © 1986 by American Physiological Society
ARTICLES |
L. G. Moore, P. Brodeur, O. Chumbe, J. D'Brot, S. Hofmeister and C. Monge
To test the hypothesis that increased hypoxic ventilatory responsiveness (HVR) raised maternal ventilation and arterial oxygenation during high-altitude pregnancy and related to the birth weight of the offspring, we studied 21 residents of Cerro de Pasco, Peru (4,300 m), while eight of them were 36 +/- 0 wk pregnant and 15 of them 13 +/- 0 wk postpartum. HVR was low in the nonpregnant women (mean +/- SE shape parameter A = 23 +/- 8) but increased nearly fourfold with pregnancy (A = 87 +/- 17). The increase in HVR appeared to account for the 25% rise in resting ventilation with pregnancy (delta VE observed = 2.4 +/- 0.7 l/min BTPS vs. delta VE predicted from delta HVR = 2.6 +/- 1.7 l/min BTPS, P = NS). Hyperoxia decreased ventilation in the pregnant women (P less than 0.01) to levels similar to those measured when nonpregnant. The increased ventilation of pregnancy raised arterial O2 saturation (SaO2) from 83 +/- 1 to 87 +/- 0%, and SaO2 was correlated positively with HVR in the pregnant women. The rise in SaO2 compensated for a 0.9 g/100 ml decrease in hemoglobin concentration to preserve arterial O2 content at levels present when nonpregnant. Cardiac output in the 36th wk of pregnancy did not differ significantly from values measured postpartum. The increase in HVR correlated positively with infant birth weight. An increase in HVR may be an important contributor to increased maternal ventilation with pregnancy and infant birth weight at high altitude.
This article has been cited by other articles:
|
|
 |
|
  K. Szdzuy and J. P. Mortola Ventilatory chemosensitivity of the 1-day-old chicken hatchling after embryonic hypoxia Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1640 - R1649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vargas, E. Vargas, C. G. Julian, J. F. Armaza, A. Rodriguez, W. Tellez, S. Niermeyer, M. Wilson, E. Parra, M. Shriver, et al. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1303 - R1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Azzam, K. Szdzuy, and J. P. Mortola Hypoxic incubation blunts the development of thermogenesis in chicken embryos and hatchlings Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2373 - R2379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Beall Colloquium Papers: Two routes to functional adaptation: Tibetan and Andean high-altitude natives PNAS, May 15, 2007; 104(suppl_1): 8655 - 8660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. E. Murphy, R. Smith, W. B. Giles, and V. L. Clifton Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus Endocr. Rev., April 1, 2006; 27(2): 141 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jensen, L. A. Wolfe, L. Slatkovska, K. A. Webb, G. A. L. Davies, and D. E. O'Donnell Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1369 - R1375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, S. Bae, and L. Zhang Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1712 - H1719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xiao and L. Zhang Calcium Homeostasis and Contraction of the Uterine Artery: Effect of Pregnancy and Chronic Hypoxia Biol Reprod, April 1, 2004; 70(4): 1171 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, X. Huang, S. Bae, C. A. Ducsay, L. D. Longo, and L. Zhang Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H716 - H722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, Y. Xiao, J. L. Estrella, C. A. Ducsay, R. D. Gilbert, and L. Zhang Effect of Fetal Hypoxia on Heart Susceptibility to Ischemia and Reperfusion Injury in the Adult Rat Reproductive Sciences, July 1, 2003; 10(5): 265 - 274. [Abstract] [PDF]
|
|
|
|
|
|
I. M. Bird, L. Zhang, and R. R. Magness Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R245 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Muza, P. B. Rock, C. S. Fulco, S. Zamudio, B. Braun, A. Cymerman, G. E. Butterfield, and L. G. Moore Women at altitude: ventilatory acclimatization at 4,300 m J Appl Physiol, October 1, 2001; 91(4): 1791 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Krampl, N. A. Kametas, P. Nowotny, M. Roden, and K. H. Nicolaides Glucose Metabolism in Pregnancy at High Altitude Diabetes Care, May 1, 2001; 24(5): 817 - 822. [Abstract] [Full Text]
|
|
|
|
|
|
D. Xiao, I. M. Bird, R. R. Magness, L. D. Longo, and L. Zhang Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H812 - H820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, C. A. Ducsay, and L. Zhang Chronic Hypoxia and Developmental Regulation of Cytochrome C Expression in Rats Reproductive Sciences, September 1, 2000; 7(5): 279 - 283. [Abstract] [PDF]
|
|
|
|
 |
|
 P. B. FRAPPELL, F. LEON-VELARDE, L. AGUERO, and J. P. MORTOLA Response to Cooling Temperature in Infants Born at an Altitude of 4,330 Meters Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1751 - 1756. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
