Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 60: 817-825, 1986;
8750-7587/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wright, J. R.
Right arrow Articles by Clements, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wright, J. R.
Right arrow Articles by Clements, J. A.

Journal of Applied Physiology, Vol 60, Issue 3 817-825, Copyright © 1986 by American Physiological Society

ARTICLES

Uptake of lung surfactant subfractions into lamellar bodies of adult rabbit lungs

J. R. Wright, R. E. Wager, R. L. Hamilton, M. Huang and J. A. Clements

The goals of this investigation were to determine whether subfractions of alveolar surfactant that have different physical and biochemical properties are preferentially taken up from the alveolar air space into lamellar bodies and to correlate the magnitude of the uptake with the properties of the fractions. Radiolabeled subfractions were obtained by differential centrifugation of lavage fluid from rabbits that had been intravenously injected with radioactive palmitate. The subfractions were P (pellet) 3 (1,000 g, 20 min), P4 (60,000 g, 60 min), P5 (100,000 g, 16 h). Subfractions were instilled into the lungs of anesthetized spontaneously breathing adult rabbits, and lavage and lamellar body fractions were isolated at later times. P3 and P4 were taken up to a larger extent than was P5 or liposomes prepared from a P4 lipid extract. The fractions that were preferentially taken up (P3 and P4) contained surfactant apoprotein (APO) 36, tubular myelin, multilamellar vesicles, and were rapidly adsorbed to an air-water interface. P3 also contained APO 10. These results demonstrate that different forms of surfactant are recycled at different rates and suggest that there is specificity in the recycling process.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Wissel, A. Lehfeldt, P. Klein, T. Muller, and P. A. Stevens
Endocytosed SP-A and surfactant lipids are sorted to different organelles in rat type II pneumocytes
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L345 - L360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Wissel, S. Zastrow, E. Richter, and P. A. Stevens
Internalized SP-A and lipid are differentially resecreted by type II pneumocytes
Am J Physiol Lung Cell Mol Physiol, March 1, 2000; 278(3): L580 - L590.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. M. Elhalwagi, M. Zhang, M. Ikegami, H. S. Iwamoto, R. E. Morris, M. L. Miller, K. Dienger, and F. X. McCormack
Normal Surfactant Pool Sizes and Inhibition-Resistant Surfactant from Mice That Overexpress Surfactant Protein A
Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 380 - 387.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Savov, R. Silbajoris, and S. L. Young
Mechanical ventilation of rat lung: effect on surfactant forms
Am J Physiol Lung Cell Mol Physiol, August 1, 1999; 277(2): L320 - L326.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Y. Haddad, B. Nieves-Cruz, and S. Matalon
Inhibition of surfactant function by copper-zinc superoxide dismutase (CuZn-SOD)
J Appl Physiol, November 1, 1997; 83(5): 1545 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. J. Gross, R. Veldhuizen, F. Possmayer, and R. Dhand
Surfactant convertase action is not essential for surfactant film formation
Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L907 - L912.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online