Journal of Applied Physiology, Vol 60, Issue 1 123-132, Copyright © 1986 by American Physiological Society

ARTICLES

Forced oscillatory impedance of the respiratory system at low frequencies

Z. Hantos, B. Daroczy, B. Suki, G. Galgoczy and T. Csendes

Respiratory mechanical impedances were determined during voluntary apnea in five healthy subjects, by means of 0.25- to 5-Hz pseudo/random oscillations applied at the mouth. The total respiratory impedance was partitioned into pulmonary (ZL) and chest wall components with the esophageal balloon technique; corrections were made for the upper airway shunt impedance and the compressibility of alveolar gas. Neglect of these shunt effects did not qualitatively alter the frequency dependence of impedances but led to underestimations in impedance, especially in the chest wall resistance (Rw), which decreased by 20-30% at higher frequencies. The total resistance (Rrs) was markedly frequency dependent, falling from 0.47 +/- 0.06 (SD) at 0.25 Hz to 0.17 +/- 0.01 at 1 Hz and 0.15 +/- 0.01 kPa X l-1 X s at 5 Hz. The changes in Rrs were caused by the frequency dependence of Rw almost exclusively between 0.25 and 2 Hz and in most part between 2 and 5 Hz. The effective total respiratory (Crs,e) and pulmonary compliance were computed with corrections for pulmonary inertance derived from three- and five-parameter model fittings of ZL. Crs,e decreased from the static value (1.03 +/- 0.18 l X kPa-1) to a level of approximately 0.35 l X kPa-1 at 2-3 Hz; this change was primarily caused by the frequency-dependent behavior of chest wall compliance.

This article has been cited by other articles:

				J. C. Cohen, J. Hudak, J. J. Fredberg, Z. Hantos, D. C. Zeldin, J. W. Card, M. A. Carey, J. W. Voltz, B. Suki, K. R. Lutchen, et al. "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease". J Appl Physiol, November 1, 2007; 103(5): 1905 - 1908. [Full Text] [PDF]

				M. K. Johnson, M. Birch, R. Carter, J. Kinsella, and R. D. Stevenson Use of reactance to estimate transpulmonary resistance Eur. Respir. J., June 1, 2005; 25(6): 1061 - 1069. [Abstract] [Full Text] [PDF]

				R. A. Watson and N. B. Pride Postural changes in lung volumes and respiratory resistance in subjects with obesity J Appl Physiol, February 1, 2005; 98(2): 512 - 517. [Abstract] [Full Text] [PDF]

				R. L. Dellaca, L. D. Black, H. Atileh, A. Pedotti, and K. R. Lutchen Effects of posture and bronchoconstriction on low-frequency input and transfer impedances in humans J Appl Physiol, July 1, 2004; 97(1): 109 - 118. [Abstract] [Full Text] [PDF]

				E. Oostveen, D. MacLeod, H. Lorino, R. Farre, Z. Hantos, K. Desager, and F. Marchal The forced oscillation technique in clinical practice: methodology, recommendations and future developments Eur. Respir. J., December 1, 2003; 22(6): 1026 - 1041. [Abstract] [Full Text] [PDF]

				L. D. Black, R. Dellaca, K. Jung, H. Atileh, E. Israel, E. P. Ingenito, and K. R. Lutchen Tracking variations in airway caliber by using total respiratory vs. airway resistance in healthy and asthmatic subjects J Appl Physiol, August 1, 2003; 95(2): 511 - 518. [Abstract] [Full Text] [PDF]

				B. Babik, T. Asztalos, F. Petak, Z. I. Deak, and Z. Hantos Changes in Respiratory Mechanics During Cardiac Surgery Anesth. Analg., May 1, 2003; 96(5): 1280 - 1287. [Abstract] [Full Text] [PDF]

				E. Bijaoui, P. F. Baconnier, and J. H. T. Bates Mechanical output impedance of the lung determined from cardiogenic oscillations J Appl Physiol, August 1, 2001; 91(2): 859 - 865. [Abstract] [Full Text] [PDF]

				J. JANE PILLOW, G. L. HALL, K. E. WILLET, A. H. JOBE, Z. HANTOS, and P. D. SLY Effects of Gestation and Antenatal Steroid on Airway and Tissue Mechanics in Newborn Lambs Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1158 - 1163. [Abstract] [Full Text]

				G. L. HALL, Z. HANTOS, F. PETAK, J. H. WILDHABER, K. TILLER, P. R. BURTON, and P. D. SLY Airway and Respiratory Tissue Mechanics in Normal Infants Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1397 - 1402. [Abstract] [Full Text] [PDF]

				C. DELACOURT, H. LORINO, M. HERVE-GUILLOT, P. REINERT, A. HARF, and B. HOUSSET Use of the Forced Oscillation Technique to Assess Airway Obstruction and Reversibility in Children Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 730 - 736. [Abstract] [Full Text] [PDF]

				F. PETAK, M. J. HAYDEN, Z. HANTOS, and P. D. SLY Volume Dependence of Respiratory Impedance in Infants Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): 1172 - 1177. [Abstract] [Full Text] [PDF]

				D. W. Kaczka, E. P. Ingenito, B. Suki, and K. R. Lutchen Partitioning airway and lung tissue resistances in humans: effects of bronchoconstriction J Appl Physiol, May 1, 1997; 82(5): 1531 - 1541. [Abstract] [Full Text] [PDF]

				W. Tomalak, R. Peslin, and C. Duvivier Respiratory tissue properties derived from flow transfer function in healthy humans J Appl Physiol, April 1, 1997; 82(4): 1098 - 1106. [Abstract] [Full Text] [PDF]