Journal of Applied Physiology
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J Appl Physiol 59: 1886-1890, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 6 1886-1890, Copyright © 1985 by American Physiological Society

ARTICLES

Effects of enhanced ventricular filling on cardiac pump performance in exercising dogs

L. D. Horwitz and J. Lindenfeld

The extent to which the normal increase in stroke volume during exercise can be augmented by increasing preload by dextran infusion was studied in seven dogs. Each dog ran 3 min on a level treadmill at mild (3-4 mph), moderate (6-8 mph), and severe (9-13 mph) loads during the control study and immediately after 10% dextran 14 ml/kg iv. During severe exercise dextran-augmented stroke volume (+5.4 ml or 19% vs. exercise without dextran, P less than 0.01) and left ventricular end-diastolic diameter and pressure did not change heart rate, aortic pressure, or maximum derivative of left ventricular pressure but decreased systemic vascular resistance by 16%. Similar increases in stroke volume and preload after dextran occurred during mild and moderate exercise when arterial pressure and heart rate were unchanged or increased and systemic vascular resistance was decreased. Thus altering preload above those levels normally encountered during exercise is a potential mechanism to increase stroke volume and cardiac output.


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N. J. A. Berger, I. T. Campbell, D. P. Wilkerson, and A. M. Jones
Influence of acute plasma volume expansion on VO2 kinetics, VO2peak, and performance during high-intensity cycle exercise
J Appl Physiol, September 1, 2006; 101(3): 707 - 714.
[Abstract] [Full Text] [PDF]


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