| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 59, Issue 5 1555-1559, Copyright © 1985 by American Physiological Society
ARTICLES |
R. K. Albert, W. Kirk, C. Pitts and J. Butler
We continuously weighed fully distended excised or in situ canine lobes to estimate the fluid filtration coefficient (Kf) of the arterial and venous extra-alveolar vessels compared with that of the entire pulmonary circulation. Alveolar pressure was held constant at 25 cmH2O after full inflation. In the in situ lobes, the bronchial circulation was interrupted by embolization. Kf was estimated by two methods (Drake and Goldberg). Extra-alveolar vessels were isolated from alveolar vessels by embolizing enough 37- to 74-micron polystyrene beads into the lobar artery or vein to completely stop flow. In excised lobes, Kf's of the entire pulmonary circulation by the Drake and Goldberg methods were 0.122 +/- 0.041 (mean +/- SD) and 0.210 +/- 0.080 ml X min-1 X mmHg-1 X 100 g lung-1, respectively. Embolization was not found to increase the Kf's. The mean Kf's of the arterial extra-alveolar vessels were 0.068 +/- 0.014 (Drake) and 0.069 +/- 0.014 (Goldberg) (24 and 33% of the Kf's for the total pulmonary circulation). The mean Kf's of the venous extra-alveolar vessels were similar [0.046 +/- 0.020 (Drake) and 0.065 +/- 0.036 (Goldberg) or 33 and 35% of the Kf's for the total circulation]. No significant difference was found between the extra-alveolar vessel Kf's of in situ vs. excised lobes. These results suggest that when alveolar pressure, lung volume, and pulmonary vascular pressures are high, approximately one-third of the total fluid filtration comes from each of the three compartments.
This article has been cited by other articles:
|
|
 |
|
  D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Mentzelopoulos, C. Roussos, and S. G. Zakynthinos Prone position reduces lung stress and strain in severe acute respiratory distress syndrome Eur. Respir. J., March 1, 2005; 25(3): 534 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The National Heart, Lung, and Blood Institute ARDS Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome N. Engl. J. Med., July 22, 2004; 351(4): 327 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Parker and M. I. Townsley Evaluation of lung injury in rats and mice Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L231 - L246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker and S. Yoshikawa Vascular segmental permeabilities at high peak inflation pressure in isolated rat lungs Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1203 - L1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Brower, L. B. Ware, Y. Berthiaume, and M. A. Matthay Treatment of ARDS Chest, October 1, 2001; 120(4): 1347 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Grishko, M. Solomon, G. L. Wilson, S. P. LeDoux, and M. N. Gillespie Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1300 - L1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Maron, Z. Fu, O. Mathieu-Costello, and J. B. West Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung J Appl Physiol, February 1, 2001; 90(2): 638 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stevens, J. G. N. Garcia, D. M. Shasby, J. Bhattacharya, and A. B. Malik Mechanisms regulating endothelial cell barrier function Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L419 - L422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Khimenko and A. E. Taylor Segmental microvascular permeability in ischemia-reperfusion injury in rat lung Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L958 - L960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Chetham, P. Babal, J. P. Bridges, T. M. Moore, and T. Stevens Segmental regulation of pulmonary vascular permeability by store-operated Ca2+ entry Am J Physiol Lung Cell Mol Physiol, January 1, 1999; 276(1): L41 - L50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Anglade, M. Corboz, A. Menaouar, J. C. Parker, S. Sanou, S. Bayat, G. Benchetrit, and F. A. Grimbert Blood flow vs. venous pressure effects on filtration coefficient in oleic acid-injured lung J Appl Physiol, March 1, 1998; 84(3): 1011 - 1023. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
